Lipitor (Atorvastatin)

Lipitor is a high-speed drug for lowering the cholesterol level in the blood. It helps to normalize the heart and the condition of blood vessels and reduce the risk of fatal heart disease. At a sufficiently high Lipitor price, the drug has many positive reviews - people value it for its reliability and effectiveness.

It is one of the hypolipidemic drugs of the statin group. The main active ingredient is the Atorvastatin component, the effect of which is the inhibition of reductase activity. This reaction is attributed to an early stage in the synthesis of cholesterol in the body, and drug Lipitor suppresses this process, resulting in a lower level of cholesterol in the blood.

The anti-atherosclerotic effect of the drug is a consequence of the influence on the components that make up the blood and walls of the vessels, resulting in a significant improvement in endothelium (the so-called dependent dilatation of blood vessels). Before taking Lipitor, it is recommended to try to reduce the amount of cholesterol in other ways: diet, exercise, weight loss for obesity and treatment of the illness that caused it. If no remedies help, prescribe this medication together with a suitable diet. Generic Lipitor reduces the risk of complication of ischemic disease by 15%. Its use helps to reduce the mortality of cardiac pathologies, reduces the risk of heart attacks and complicated attacks of angina by 25%. The drug has no mutagenic and carcinogenic properties.

Indications for use are the presence of the following health problems:

• hypercholesterolemia;

• combined hyperlipidemia;

• disbetalipoproteinemia;

• hypertriglyceridemia;

• a high risk of developing CHD (age 55, smoking, diabetes, heredity, hypertension, etc.);

• symptoms of ischemic heart disease.

The drug is suitable for people with hypercholesterolemia, which is not amenable to treatment with diet and other lipid-lowering medications. As a result of treatment, the cholesterol level drops by 30-45% and the LNLP by 40-60%. In this case, increases the amount of a-lipoprotein in the blood.

Doctors usually do not prescribe it people with hypersensitivity to the components of the drug, children under the age of 18, and also having an active hepatic disease or elevated for an unknown reason the level of transaminases in the blood plasma. Pregnant women and breastfeeding should not take Lipitor. If necessary, treatment should be temporarily abandoned breastfeeding. Women of childbearing age in the treatment should use adequate contraception. To prescribe the drug is allowed only at low probability of pregnancy, since there is a strong negative impact on the fetus. People who have a history of liver disease, or who drink excessively, should take the drug with extreme caution. Be sure to read the instruction if you prefer to purchase Lipitor online.

The medicine must be taken orally once a day, the obligatory condition is to use at the same time. Taking food does not affected taking of medication.

There are no restrictions on the time of taking the tablets. The daily dosage is 10-80 mg, the exact norm is calculated based on the parameters of LNLP (harmful cholesterol), individual drug tolerance and the purpose of admission. For example, if a patient suffers from primary hypercholesterolemia or combined hyperlipidemia, it is sufficient to take 10 mg daily for 2-4 weeks. In the case of hereditary hypercholesterolemia, a maximum dosage of 80 mg is used.

Taking medication together with cyclosporine, nicotinic acid, erythromycin, azole derivatives, fibrates and antifungals increases the risk of myopathy. Antacids (suspensions with magnesium and aluminum hydroxide) significantly reduce the concentration of main substance in the blood plasma, but do not affect its hypolipidemic effect.

Inhibitors of the isoenzyme CYP3A4 and transport protein OATP1B, diltiazem, intraconazole, as well as grapefruit juice in large quantities cause an increase in the concentration of drug. The combined use of medication and colestipol increases the lipid-lowering effect of both drugs, but the concentration of Atorvastatin in the blood drops by about a quarter. The level of digoxin in the blood, when combined with 80 mg Lipitor, increases to 20%, so with such a combination the patient should be monitored in a hospital setting. The amount of norethisterone and ethinylestradiol (oral contraceptives) in the blood increases by 20-30% if taken with Lipitor.

When the Lipitor dose is increased, it is important to check the lipid level in the plasma and adjust the amount of Lipitor taken in accordance with the indices. In liver failure or joint admission with Cyclosporin is allowed to take no more than 10 mg per day, with kidney disease or in the elderly, no dosage restrictions are required.

• The liver should be monitored at the following times: beginning of treatment, after 1.5, and then after three months of therapy with the drug in question. The activity of liver enzymes is observed within 70-90 days after the initiation of admission.

• Patients who have an increase in liver transaminase activity are under strict medical supervision.

• The therapy should be suspended or even discontinued in the development of severe conditions.

• In case of unexplained pain, weakness in the muscles, malaise or fever, the patient must immediately consult a doctor.

In the treatment with Lipitor in 1-10% of cases, patients observe:

• Asthenia (chronic fatigue syndrome);

• Insomnia;

• Pain in the abdomen or in the head;

• Indigestion and diarrhea;

• Constipation and flatulence;

• Myalgia;

• Nausea.

Less than 1% of patients have:

• Anaphylaxis;

• Anorexia;

• Arthralgia;

• Pain and muscle cramps;

• Hypo- or hyperglycemia;

• Dizziness;

• Jaundice;

• Skin rash, hives, itching;

• Myopathy;

• Memory impairment;

• Sensitivity disorders;

• Neuropathy;

• Pancreatitis;

• Bad feeling;

• Vomiting;

• Thrombocytopenia.

In rare cases, there may be edema of limbs, obesity, chest pain, secondary renal failure, baldness, and tinnitus.

Lipitor is sold if a prescription is available but also you can buy Lipitor online without prescription in Denmark online pharmacy. The product should be stored in a dark and dry place protected from sunlight at an air temperature not exceeding 25 degrees. Storage space should be out of the reach of children. You can use the drug during 3 years from the date of manufacture. At the end of this period, the use of the drug is prohibited.