Isordil (Isosorbide Dinitrate)

Diseases of the cardiovascular system are the most common pathologies of public health. The causes of this ailment are stressful situations, daily psychological, mental stress, and an intense rhythm of life. All these factors lead to a decrease in immunity, a lack of necessary vitamins for normal cardiac activity and the vascular system. People with such problems need to be prescribed drugs that contribute to the normalization of blood flow in the vessels and ensure the normal operation of the heart muscle.

Isordil reduces the tone of the walls of venous vessels. It promotes relaxation of smooth vascular musculature. The drug expands the peripheral venous vessels and arteries, which leads to an increase in the volume of venous vessels. Thus, there is no reverse venous outflow to the heart.

The effect on the arterial vessels provides a reduction in their postload (system resistance), which greatly facilitates the work of the heart muscle: the oxygen consumption of the myocardium decreases.

Dinitrate isosorbide redistributes the bloodstream in the subendocardial layers, when coronary blood flow is reduced due to the presence of atherosclerotic plaques. Expansion of the vessel walls is caused by nitrates and promotes perfusion of the poststenotic region of the myocardium. Due to nitrates, venous spasms decrease due to the expansion of eccentric coronary stenosis. In patients with chronic heart failure, due to nitrates, hemodynamics improves at rest and under load.

This effect is achieved by reducing the need for myocardium in oxygen and reducing the regurgitation of the heart valves. Dinitrate isosorbide also affects other systems of organs, contributing to the relaxation of the bronchial muscles, the walls of the digestive tract, the urinary and cholagogue tracts.

It gives off nitric oxide, which leads to a decrease in vascular tone and smooth muscle by producing guanylate cyclase and increasing the concentration of cyclic guanylate monophosphate. Due to a change in protein phosphorylation in the smooth muscle cells, dephosphorylation of proteins takes place. Reduces the contractility of the myocardium.

After application of the drug, isosorbide dinitrate has good absorption in the digestive tract (after about 20 minutes). The highest concentration in the blood is achieved within 15 - 100 minutes after the procedure of admission. After the primary passage through the hepatic filtration is metabolized by enzyme denitration.

The bioavailability of the unchanged substance formula is about 30%. With continued use, bioavailability increases. In an unchanged form with faeces and urine, an insignificant amount of substance is excreted.

The drug Isordil is indicated in the presence of violations of cardiac activity and other vascular disorders:

• angina pectoris (including unstable) for prevention and elimination;

• acute myocardial infarction (also in the complicated form of acute left ventricular failure);

• post-infarction;

• spasms of the coronary arteries (for treatment with a cardiac catheter and for prophylactic purposes);

• heart failure in chronic course;

• pulmonary edema;

• hypertension (with a violation in the small circle of blood circulation);

• spasms of peripheral vessels (angiostatic retinitis, obliterating endarteritis);

• pulmonary heart (with therapy in a complex).

Since the drug has a serious effect on vascular activity, there are contraindications for use:

• hypersensitivity to the components of the drug;

• intracranial pressure (due to trauma or hemorrhagic stroke);

• arterial hypotension in severe form;

• hypovolemia;

• bleeding;

• insufficiency of blood circulation in acute form (vascular collapse, shock);

• cardiogenic shock;

• myocardial infarction in acute form

• angina in hypertrophic cardiomyopathy;

• lung disease at the initial stage;

• severe anemia;

• impaired kidneys or liver in severe conditions.

The drug can be used both with monotherapy and as part of complex treatment. With the withdrawal of the drug, it is recommended to gradually lower the dosage, without abruptly refusing the medication. Capsule or tablet is swallowed.

One dose is 10 to 20 mg. On the day should take 5-6 doses 60 minutes before meals or two hours later. When the treatment is prescribed after three days, the dose may be longer (up to 120 mg per day). The number of tablets taken to 20 mg is 3-4 times a day, for tablets with a long action of 20 mg (retard) - 2-3 times, taking tablets 40-60 mg twice a day, 120 mg once. Read the instruction before the therapy if you prefer to buy Generic Isordil online.

As a result of the interaction of Isordil with other drugs, a reaction is possible:

• with alpha-blockers or with beta-adrenostimulators. Reduction of the antianginal effect of isosorbide dinitrate, which can be expressed in tachycardia or a decrease in blood pressure;

• with Propranol, Amiodarone, calcium channel blockers. Increased antianginal effect;

• with vasodilators, neuroleptics, quinidine, antihypertensive drugs, ethanol, Procainamide, adrenoblockers, sildenafil. Strengthening of hypotensive effect;

• with m-holinoblokators. Increase of eye pressure.

• when using adsorbents, astringents, the absorption of Isordil decreases.

The use of other drugs with Isordil must always be agreed with the doctor.

Long-term use of the drug in high dosage can lead to a decrease in the effectiveness of Isordil. To avoid loss of the effect of the drug, it is necessary to monitor its reception. Perhaps a break in treatment for a few days will help restore the effect of the drug.

Persons whose occupations are associated with concentration (or driving) should be careful when taking Isordil. Because of the presence of glucose in the drug, Isordil is not recommended for patients with lactase deficiency or galatosemia. In pregnancy, the drug cannot be used.

When taking the medication, in addition to the positive effect, the Isordil side effect may appear:

• headache, dizziness. It often occurs during the first days of therapy;

• redness of the skin, a feeling of heat, low blood pressure;

• arterial hypotension with signs of cerebral ischemia (drowsiness, visual absent-mindedness, weakness) and reflex tachycardia;

• sweating (usually with left ventricular failure);

• exacerbation of stenocardia attacks;

• alveolar hypoventilation with the possibility of occurrence of myocardial infarction in persons with ischemia;

• glaucoma.

Keep the preparations regardless of the form of release at a temperature of not more than + 25 ° C. The storage location should be dry, darkened and unattainable for children. The shelf life of the drugs should be indicated on the packaging, no more than five years. You can buy Isordil without prescription in different online pharmacies like Norway online pharmacy.