The diagnosis of "Hepatitis C" is often unexpected and significantly changes the habitual way of life of the patient. A natural desire is to find safe and effective medicines. Today, one of the drugs which have a powerful antiviral effect is Ledipasvir. This drug suppresses the activity of protein NS5A without which the reproduction of the virus is impossible. It is worth noting that in itself it is not used but is effective only in conjunction with the drug Sofosbuvir, therefore, received the abbreviated name (SOF + LED). Each tablet contains 90 mg of Ledipasvir and 400 mg of Sofosbuvir.
In what kind of disease treatment Harvoni is helpful?
Harvoni is the newest drug developed to treat the first and fourth genotype of the hepatitis C virus but it is ineffective in patients with genotypes 2 and 3 (the rest of the genotypes are not considered here, as they are rare).
What should I tell my health care provider before I takeGeneric Harvoni?
Usually when you buy Harvoni in online pharmacy doctor should warn you that you should not take medication with intolerance of the active substance or any of the components. It is not prescribed for persons less than 18 years of age. Harvoni is not prescribed to pregnant women and women during lactation. The drug is contraindicated for people who are allergic to the active substance of the medication, as well as in cases when the patient is prescribed other drugs containing Sofosbuvir. Before you start taking it carefully read the instructions for use.
In general, SOF + LED with caution should use the medicine in the following cases:
• Cirrhosis of the liver or condition after liver transplantation, other operations;
• Pregnant women or when planning pregnancy. Avoid pregnancy within a month after the end of therapy;
• People of advanced age;
• With lactose intolerance.
How should I take Harvoni?
Tablets are taken daily at the same time once a day, preferably after meals, washed down with a small amount of water. There is no need to crack the tablets. Do not increase or decrease the Harvoni dosage of the drug. If unwanted side effects develop you need to see a doctor. If the reaction worsens, it is worthwhile to refrain from driving vehicles.
Dosage information
The duration of treatment can be 12-24 weeks. However, the doctor can adjust the duration of therapy, both in the smaller and larger way. Patients with 1 genotype of the hepatitis C virus are recommended to be treated within 12 weeks. Patients with compensated cirrhosis need to take the generic Harvoni 24 weeks.
Patients
Without cirrhosis, untreated and those who were not helped by previous treatment based on Interferon-a and Rib
With compensated cirrhosis, untreated patients and those who were not helped by previous treatment based on Interferon-a and Ribavirin (Rib)
Repeated treatment after therapy containing one or more inhibitors
Genotype 1a
Untreated: 8-12 weeks without Rib
Passed treatment: 12 weeks with Rib or 24 weeks without it
Untreated: 12 weeks without Rib
Passed treatment: 12 weeks with Rib or 24 weeks without it
Previously treated with Interferon + Rib + Telaprevir or Boceprevir, Telaprevir or Simeprevir - 12 weeks with Rib
Previously treated according to the scheme: just Sofosbuvir or with + Ribavirin or with Interferon + Rib - 12 weeks with Rib (F0-F2) or 24 weeks with (F3-F4)
Genotype 1b
Untreated 8-12 weeks without Rib
Passed 12 weeks treatment, without Rib
12 weeks without Rib
Previously treated with Interferon + Rib + Telaprevir or Boceprevir, Telaprevir or Simeprevir - 12 weeks with Rib
Previously treated according to the scheme: just Sofosbuvir or with + Rib or with Interferon + Rib - 12 weeks with Rib (F0-F2) or 24 weeks with (F3-F4)
What may interact with Generic Harvoni?
Do not take the pill with another medication that contains Sofosbuvir - there may be an overdose and an increase in side effects. Categorically is prohibited simultaneous reception with Tenofovir, Elvitegravir and Emtricitabine.
Do not take Harvoni together with Tipranavir, Saint-John's-wort, Rosuvastatin or Phenytoin. These drugs interfere with the absorption of drug and can affect the effectiveness of treatment.
There are a number of drugs that reduce the effectiveness of SOF + LED:
1. Rifabutin.
2. Rifampicin.
3. Oxcarbazepine.
4. Phenobarbital.
The combined use of SOF + Led with Simeprevir increases the risk of side effects. Also, with the combined use of Digoxin or Rusovastatinthere may be an increase in the severity of the side effects of the first two drugs.
What should I watch for while taking Harvoni?
After 12 weeks of therapy, blood should be given to determine the virus. If a sustained virologic response is not observed after 12 weeks of treatment, therapy should be discontinued. This means that in your particular case the medicine was ineffective and it is necessary to select another drug.
Before starting therapy, always consult your doctor.
Consultation with the attending physician is necessary in cases when:
1. During treatment, you are planning a pregnancy or breast-feeding.
2. There are liver or kidney diseases.
3. You take other medicinal or homeopathic remedies.
4. There is a tendency to allergic reactions to medicines.
All this can not only reduce the effect of the drug, but also lead to complications. For any manifestations of complications you should immediately consult a doctor. Side effects are fixed locally.
Important! The course of treatment should be incompletely completed, even after the viral RNA is undetected after the first weeks of treatment. Otherwise, a relapse of the disease is possible!
What side effects may I notice from Generic Harvoni?
Clinical studies have shown that in most cases, medicine is well tolerated by patients so if the dosage is correct and there are no contraindications, Harvoni side effects are almost not manifested. When taking the medicine, the following may occur:
1. Nausea.
2. Dizziness.
3. Muscular weakness.
4. Migraine.
5. Disorder of appetite.
Where can I keep Harvoni?
Keep Harvoni in a dry place, protected from sun and inaccessible to children. Do not take the drug after the expiration date indicated on the package. Store the drug at the room temperature. Also you can buy Generic Harvoni online in Canada.
