The effectiveness of the combination of Sacubutril + Valsartan, is due to the simultaneous suppression of the effectiveness of non-lysine metabolite Sacubutril and the action of Valsartan - an antagonist of angiotensin receptors of the second class.
Complementary positive effect of the complex substance on the kidneys and myocardium in people suffering from heart failure is explained by the increase in the level of the pethids, which are split by non-saline, which is due to the effectiveness of the metabolites of Sacubutril. At the same time, Valsartan neutralizes the negative effect of angiotensin 2.
Activation of membrane-bound receptors by natriuretic peptides, interconnected with guanylate cyclase, leads to an increase in cGMP concentration, which causes vasodilation, increased sodium naresis and diuresis, increased GFR and blood flow in the kidneys. This prevents vascular narrowing, fluid retention in the kidneys and sodium, active cell growth and proliferation.
According to clinical studies, the use of a complex drug reduces the percentage probability of death due to the developed pathological process in the cardiovascular system, the number of hospitalizations of patients with an attack of acute heart failure decreases.
Thus, it is possible to judge a 20% reduction in sudden deaths due to acute coronary insufficiency. This factor is facilitated by the complex of two active components. This result was evaluated during the course of taking the drug. If the complex agent is applied by a month course, the daily dose of which is divided into two doses, then the concentration of active components in the blood is reached after three days.
In what kind of disease treatment Entresto is helpful?
The complex medication Entresto, is assigned in the following cases:
• For chronic heart failure, second, third and fourth grade;
• In patients with systolic dysfunction in order to reduce the likelihood of death and hospitalization from a cardiovascular attack;
• In high blood pressure;
• In case of kidney diseases;
• In other heart problems.
What should I tell my health care provider before I take Generic Entresto?
A complex drug is not recommended for use in the following cases:
• In increased sensitivity to one of the components or additional substances;
• With simultaneous use of angiotensin converting enzyme inhibitors. It is not recommended to use the medication after 36 hours after stopping the use of angiotensin converting enzyme inhibitors;
• In the presence of angioedema, which followed after the use of ACE inhibitors or ARA of the second type;
• With a moderate or severe decrease in kidney function;
• In severe hepatic diseases, biliary cirrhosis and cholestasis;
• Patients under the age of eighteen, since there is no information proving the efficacy and safety of the use of the complex medicinal product;
• During pregnancy, in all trimesters, in planning and during lactation;
• With simultaneous use of drugs containing ARA of the second type, this is due to the presence of Valsartan in the formulation.
How should I take Entresto?
A pill should be taken orally and washed down with water. The use of the combined drug Entresto does not depend on the intake of food.
Dosage information
The target or maximum daily dose of the combined drug is 200 mg twice daily. However, the recommended initial dose does not exceed 100 mg twice daily.
Patients who did not use ACE inhibitors or ARA of the second type in therapy or used them in small doses, the course of treatment begins with 50 mg twice a day, with a gradual increase in dosage.
To increase daily Entresto dosage is necessary once every three to four weeks, depending on the tolerability of the drug, to reach a maximum dose of 200 mg twice daily.
As already mentioned, the drug should be consumed no earlier than 36 hours after discontinuation of use of drugs, which include an ARA of the second type.
If there are problems with the use of a complex drug (a significant reduction in blood pressure, a cessation of normal kidney function and hyperkalemia), it is worthwhile to reduce the daily dose used, and to perform a general dosage adjustment.
What may interact with Generic Entresto?
As already mentioned, the drug should be consumed no earlier than 36 hours after discontinuation of use of drugs, which include an ARA of the second type. About other interactions you can ask a doctor or read in instruction which you can find in a package if you buy Generic Entresto online.
What should I watch for while taking Entresto?
It is forbidden to use during pregnancy as this drug can harm your future child.
If there is a pronounced decrease in blood pressure, consideration should be given to correcting the dose of diuretics.
What side effects may I notice from Generic Entresto?
Among the possible Entresto side effects are the following:
• The development of hyperkalemia is quite common;
• Negative reactions from the nervous system. The most typical loss of orientation, acute headache, probably the development of orthostatic dizziness;
• Negative phenomena from the organs of hearing. The most frequent manifestation is vertego;
• One of the side effects is a sharp lowering of blood pressure and orthostatic hypotension;
• Negative manifestations on the part of the respiratory system;
• Development of violations in the organs of the gastrointestinal tract;
• The onset of an allergic reaction, angioedema;
• Malfunctioning of the kidneys and urinary tract;
• Increased fatigue, fatigue.
In the case of an overdose, a sharp drop in blood pressure develops, requiring medical intervention. Treatment symptomatic: gastric lavage, the introduction of sodium chloride solution, measures to maintain the cardiovascular system and kidneys.
Where can I keep Entresto?
As it is considered as a dangerous medication you should keep it in a safe place, far away from children. After the expiration date you should not take it. Packaging should be stored at certain rules: at a room temperature, avoiding high humidity. You can also buy Entresto without prescription in Turkey online pharmacy.
