This drug refers to preparations intended for the treatment of diseases of the cardiovascular system. During the use of the drug, the number of hepatic receptors on the cell membranes increases, which subsequently leads to an increase in catabolism and capture of low-density lipoproteins, as well as suppression of very low density lipoprotein formations. The end result of the drug is a marked decrease in the content of very low and low density lipoproteins in the patient's blood serum. It is able to reduce the levels of triglycerin, LDL cholesterol and total cholesterol.
In what kind of disease treatment Crestor is helpful?
Direct indications for the use of this medication are such diseases or conditions of the patient:
condition with increased serum cholesterol levels or primary hypercholesterolemia;
family homozygous hypercholesterolemia;
hypertriglyceridemia;
atherosclerosis;
diseases of the cardiovascular system.
What should I tell my health care provider before I take Generic Crestor?
Contraindications constitute a more extensive list of diseases and conditions:
hepatic diseases, their active phase, including persistent increase in serum activity of transaminases;
in combination in one therapy with cyclosporine;
children and adolescents under 18;
deficiency of lactase;
intolerance to lactase;
glucose-lactose malabsorption;
periods of breastfeeding and lactation;
individual intolerance of any of the components that are part of this lexredium.
Dosages of tablets 5, 10 and 20 mg have a separate list of contraindications:
myopathy;
pronounced functional renal impairment;
individual predisposition to the development of myotoxic complications.
For tablets with a volume of 40 mg, the contraindications will be as follows:
alcoholism;
there are risk factors for myopathy or rhabdomyolysis (renal failure of moderate severity, hypothyroidism, ancestral history of muscle diseases, myotoxicity against fibrates and other inhibitors of HMG-CoA reductase in history);
conditions in which an increase in the plasma concentration of rosuvastatin is possible;
combination with fibrates in one therapy;
belonging of the patient to the Mongoloid race.
How should I take Crestor?
Drug Crestor must be taken orally, with enough water to drink a single dose of tablets, regardless of the time of meals, at any time of the day. Do not grind or chew tablets.
Dosage information
The dosage of this medication in each individual case is chosen by the attending physician depending on the clinical indications, the goals of the therapy and the therapeutic response to the treatment.
The initial dosage, as a rule, is 5-10 mg of the drug. Multiplicity of its reception is once a day. An increase in dosage may be necessary, but it is carried out only one month after initiation of therapy with minimal doses. It is very important to keep under control the lipid metabolism.
What may interact with Generic Crestor?
Reception of drug together with anticoagulants of indirect action is reduced to an increase in prothrombin time. In the event that the use of drug is stopped or the dosage is reduced, the international normalized time is reduced. Therefore, its constant monitoring is necessary.
With the simultaneous administration of Crestor with erythromycin, a decrease in the maximum density by one third of the total is observed. The effect is due to increased motor functions of the intestine.
Antacids which include aluminum and magnesium hydroxide can reduce the concentration of active substance in the blood of the patient by half with a joint reception. If you use them after a two-hour period after taking Crestor, then a decrease in the expression of this effect is observed. Digoxin does not interact clinically.
The use of Crestor in conjunction with human immunodeficiency virus protease inhibitors, the growth of main substance in the blood is observed. During the appointment of medication, patients with HIV should take into account the compliance of the hazard and positive points at the beginning of treatment and with the addition of dosage. There is a danger of formation of myopathy with the joint administration of drug with inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase. Admission simultaneously with hypolipidemic drugs increases the concentration of rosuvastatin in the patient's blood by 2 times.
What should I watch for while taking Crestor?
The drug should not be taken by pregnant women and breastfeeding mothers. If the appointment is unavoidable, breastfeeding stops. Women, before taking the drug should make a pregnancy test. When the drug is used, it is necessary to use reliable contraceptives.
In cases of prescribing the patient immediately dosage of the drug equal to 40 mg, it is very important to keep the functional renal parameters under control.
At the initial significantly increased level of creatine phosphokinase (more than five times increased) before the start of therapy with the help of it in a week it is necessary to re-measure it. And if the result is the same - therapy cannot be started.
In case of manifestation of muscle soreness or weakness, or muscle spasms, you should immediately contact your doctor. This may be a sign of increased levels of creatine phosphokinase. The reappointment of this pharmaceutical can be only after the normalization of all indicators and with a reduced dosage. Since the use of the drug may cause dizziness, care must be taken when performing work associated with a high concentration of attention and speed of psychomotor reactions.
What side effects may I notice from Generic Crestor?
In some cases, the following undesirable effects may occur:
• dizziness;
• tubular proteinuria;
• rashes;
• urticaria;
• itching;
• allergic reactions;
• myopathy.
There is no special treatment for drug overdose. If an overdose has occurred, it is necessary to carry out treatment, according to the symptoms. If necessary, carry out additional supporting activities. A process of monitoring the proper functioning of the liver and the degree of creatine phosphokinase is mandatory.
Where can I keep Crestor?
The drug should be stored in a place inaccessible to children at a temperature regime not exceeding 30 ° C. It is a prescription medication but you can buy Crestor without prescription in international pharmacies, for example, in Spain online pharmacy.
