Ziac (Biosoprolol - Hydrochlorothiazide)

What is Generic Ziac?

Hypertension most often is chronic. Patients have to take pills to reduce pressure, because in high rates there is an increased stress on the heart. Hypotensive drugs are of different mechanisms of action and are distinguished by single-component and combination. The latter often include diuretics. These drugs include Ziac. The attending physician selects the drug based on the patient's condition. Do not select the medicine yourself.

Ziac medication refers to combined antihypertensive drugs. It reduces the pressure due to the combined action of two components: an adrenoblocker and a diuretic.

During treating patients should monitor the heart rate and blood pressure (at the beginning of therapy every day). For patients who suffer from diabetes, glucose monitoring in the laboratory is mandatory, because the drug eliminates the symptoms of low sugar. Patients over 65 years of age need to monitor the kidneys.

In the composition of Ziac are the two main active substances that supplement each other's hypotensive action:

1. Bisoprolol is an adrenoblocker. Reduces blood pressure in blood vessels, stabilizes the heart rate, and reduces the need of the heart in oxygen. It, like other adrenoblockers, can provoke a depressed patient. If this happens, you should change the medicine.

2. Hydrochlorothiazide is a diuretic. It removes excess fluid from the body, as a result, the total volume of blood in the vessels decreases and the pressure decreases.

In what kind of disease treatment Ziac is helpful?

It is used to treat people suffering from moderate to mild hypertension.

What should I tell my health care provider before I take Generic Ziac?

Contraindications include:

• hypersensitivity to sulfonamides (including hydrochlorothiazide);

• increased sensitivity to bisoprolol and other components of the drug;

• cardiogenic shock;

• chronic heart failure (decompensation stage), in the event that it does not lend itself to drug therapy;

• severe forms of bronchial asthma, COPD - chronic obstructive pulmonary disease;

• syndrome of weakness of the sinus node, incl. sinoatrial blockade;

• bradycardia expressed (with a heart rate less than 50 beats per minute);

• atrioventricular blockade of degree III and II without an artificial pacemaker;

• hypotension arterial;

• variant angina pectoris (Prinzmetal angina);

• hypokalemia;

• pheochromocytoma (without joint application of alpha-blockers).

How should I take Ziac?

When the drug is consumed with food it improves the absorbability of Ziac. You cannot grind or chew the remedy, you need to swallow the whole tablet and wash it down with water.

Dosage information

The dosage and duration of the course is chosen by the attending physician on the basis of analyzes and patient examination data.

Begin with a minimum daily amount: 2.5 mg / 6.5 mg once a day. The dose can be doubled after 10-14 days if the desired effect is not achieved.

With a one-time admission of a medicine, a repeated increase in pressure after 24-72 hours is possible, for a long-term effect and stabilization of the condition; reception from a month is required. Normalization of pressure occurs already after five days of reception. Read carefully the instruction especially if you buy Generic Ziac online.

What may interact with Generic Ziac?

It is forbidden to combine drug Ziac with the following medications:

• medicines to normalize the heart rate - the contractile function of the heart worsens, until the stop;

• calcium channel blockers (verapamil) - a significant reduction in heart rate;

• antihypertensive agents of central action - the work of the heart worsens.

If there are doubts: whether it is possible to combine Ziac treatment with the administration of certain medications - you should consult a doctor.

With caution and under medical supervision take it with:

• adrenomimetics - reduces the hypotensive effect of the drug;

• Mefloquine (antimalarial drug) - a pronounced bradycardia develops;

• immunostimulants, iodine - allergic reaction is amplified, anaphylactic shock may develop;

• Phenytonin - excessively lowers blood pressure;

• Lidocaine - reduces the rate of excretion from the body;

• Insulin and other drugs to maintain normal blood glucose levels - the action of Ziac changes;

• diuretics - orthostatic hypotension develops (pressure drop when body position changes);

• non-steroidal anti-inflammatory drugs, other antihypertensives - Ziac enhances action;

• Lithium-containing drugs - the intoxication of the organism develops, due to the deterioration in the excretion of lithium.

What should I watch for while taking Ziac?

In addition, Ziac is not used by children as well as pregnant and lactating women. Influence on the fetus has not been studied. The drug enters the baby through breast milk, so it is contraindicated during lactation. If necessary, breastfeeding is discontinued.

What side effects may I notice from Generic Ziac?

Frequent side effects of Ziac (up to 10% of cases) include:

• bradycardia (slow heartbeat);

• discomfort, a feeling of heaviness in the heart;

• hypotension;

• feeling cold in the limbs;

• weakness, loss of strength;

• headache;

• sleep disorder;

• dizziness;

• depressed state;

• indigestion and stool;

• feeling dryness of mucous eyes, mouth, nose;

• stomach ache.

Allergy to the drug is rare, mostly manifested by rashes on the skin, itching. In rare or rare cases, there were observed:

• worsening of the health in chronic heart failure;

• swelling;

• angina pectoris;

• impaired consciousness;

• hallucinations;

• temporary deterioration of vision;

• inflammatory diseases of the nasal mucosa, eyes, mouth;

• liver disease;

• distortion of taste perception;

• impairment of sexual desire, temporary erectile dysfunction;

• increased sweating;

• redness of the skin.

It can cause unwanted reactions or aggravate the condition if the patient:

• an allergic reaction to adrenoblockers or sulfonamide derivatives;

• obstructive pulmonary disease;

• bronchial asthma, which occurs in severe form;

• chronic uncompensated heart failure;

• diabetes mellitus, which poorly regulates blood sugar;

• disorders in the sinus node;

• the heart rate is significantly reduced (heart rate is 50 beats per minute and less);

• Severe cases of impaired peripheral blood flow;

• impaired liver or kidney function in acute or chronic form;

• lactase digestion disorders.

Where can I keep Ziac?

The drug can be used within 36 months from the production date. To maintain medicinal properties throughout the shelf life, the drug should be stored in a temperature range of 55 to 75 degrees, in a darkened place. You can also buy Ziac without prescription in international pharmacy like Spain online pharmacy.