Medication Zetia can reduce cholesterol absorption by more than 50% when compared with placebo.
The principle of the drug is fundamentally different from medications of similar action. It is localized in the small intestine and partially blocks the absorption of cholesterol. Simultaneous use of medicine and food (regardless of the percentage of its fat content) does not interfere with its basic work. The drug begins to act actively within an hour after admission, the maximum concentration in the blood reaches after 2-3 hours.
Its appointment should be preceded by a diet with a complete lack of animal fats. During the course of treatment, the patient should continue to observe the diet with a strict restriction on the amount of any easily digestible fat.
In what kind of disease treatment Zetia is helpful?
Indication for use is primary hypercholesterolemia, i.e., an excessive content of fat-containing substance in the plasma and homozygous familial hypercholesterolemia, one of the hereditary forms of metabolic disorders.
In one case, Zetia from cholesterol is used to adjust the CL index in plasma. In 2 situations, patients on the advice of a doctor are assigned only statins or in combination with this agent to reduce the risk of developing cardiovascular pathologies.
What should I tell my health care provider before I take Generic Zetia?
• expecting women, as well as during breastfeeding (during the course of the drug it is necessary to stop feeding);
• hypersensitivity to the components of the drug;
• in case of severe liver diseases or the high activity of "liver" transaminases;
• medium and severe (child-pugh score) degree of liver disease;
• the age of 18 years (the effectiveness of therapy, as well as its safety is not established);
• in the simultaneous administration of fibrates (the effectiveness of therapy, as well as its safety is not established).
How should I take Zetia?
This medication should be taken orally and a pill should be washed down with water.
Dosage information
Before the beginning of the course of therapy, as well as during its behavior, patients should adhere to lipid-lowering dietary nutrition. The medication is allowed to be taken orally at any time, eating does not affect the effectiveness of the medication. The recommended dosage of the drug for mono- or combined treatment (+ statins) is 10 mg once a day. The medication is allowed to be taken during meals, and between its methods. There is no need to prescribe an individual Zetia dosage in the elderly or patients with impaired renal function. If you buy Generic Zetia online more detailed instruction you can find in the packaging.
What may interact with Generic Zetia?
Interaction with other drugs:
1. Simultaneous use with antacids reduces the absorption of the drug, but it does not influence its work.
2. Use in combination with Cholestyramine digestibility of the drug reduces by more than 50%.
3. Admission simultaneously with Fenofibrate (Tricor) or Gemfibrozil, on the contrary, increases its effect by about 1.5 times.
4. Cyclosporine significantly increases the concentration of the standard dose of Zetia. To avoid negative reactions when using these drugs, there should be strict monitoring by the attending physician. It is necessary to inform the doctor about the medications being taken.
What should I watch for while taking Zetia?
In order to avoid hypercholesterolemia, several simple complex actions should be followed, which reduce the risk of cardiovascular deviations. This is a healthy food, eliminating too fatty foods, eating lots of vegetables, controlling body weight. The refusal of alcohol and cigarettes several times reduces the risk of occurrence of ischemia.
Experiments on small animals did not show a direct or indirect adverse effect on the fetus, as well as its development, childbirth and the further development of the child. Injections to pregnant mice with drugs in combination with such drugs as lovastatin, simvastatin, pravastatin and atorvastatin, did not produce side effects. During tests on rabbits, damage to the development of the skeleton in the fetus was rarely seen. These experiments did not show that the drug can be excreted in breast milk. Because of this, for the period of lactation it is worth not to take the medication.
What side effects may I notice from Generic Zetia?
Clinical studies of 2 to 3 months showed good tolerability at the recommended dosage of 10 mg per day for mono- or combined therapy (+ statins). Adverse reactions are often not significant and pass on their own. The frequency of occurrence of adverse reactions and the frequency of the need for withdrawal is the same as with placebo. In subjects with 1 to 10% who received treatment with Zetia in mono or combination therapy (+ statin), the following adverse reactions were noted.
Monotherapy: headaches, the occurrence of pain in the stomach, problems with the stomach.
Combined treatment with statin: headaches, decreased strength, abdominal pain, intestine problems, excessive gas formation, fainting, myalgia. Laboratory studies showed a significant increase in hepatic transaminases (alanine aminotransferase and / or aspartate aminotransferase more than 3-fold). This increase in indicators is often asymptomatic, seen both with therapy and after withdrawal of the course of admission.
Where can I keep Zetia?
Store in the original packaging at a temperature not exceeding 30 ° C in a place with a low humidity. Do not let your kids play with it. You can also buy Zetia without prescription in Spain online pharmacy.
