Hyzaar (Losartan-hydrochlorothiazide)

Hyzaar is a medicine aimed at eliminating arterial hypertension. The agent includes several active ingredients that together show excellent results, quickly cope with the unpleasant symptoms caused by the disease. The medication has a number of contraindications, it should be taken only after permission of the doctor. Take into account the necessary dosage, the method of use.

Violation of the rules specified in the instructions to the preparation is fraught with the occurrence of side effects. Hyzaar components show excellent results in reducing high blood pressure compared to analogues that include only one active substance. The drug includes two main components: losartan and hydrochlorothiazide, the latter increases the activity of plasma renin, aldosterone secretion, significantly lowering the level of potassium in the blood plasma of the patient, which has a beneficial effect on the level of angiotensin II. In view of the inhibition of aldosterone, the active component of Hyzaar reduces potassium-induced losses caused by diuretics.

Lozartan has an easy diuretic effect, while hydrochlorothiazide significantly increases the production of uric acid, a combination of these effects have a mild elimination of hyperuricemia caused by the action of diuretics. The antihypertensive effect of taking Hyzaar persists throughout the day, providing excellent well-being of the patient, reduces the risk of hospitalization against the background of hypertension.

Some clinical studies insist that a positive effect persists for a year if the drug has been taken for a long period of time. Despite a significant reduction in blood pressure, the drug does not significantly affect the patient's heart rate. The combination of active components of drug Hyzaar shows excellent results regardless of the sex and age of the patient, the remedy is effective at all stages of the development of hypertension.

After taking the drug inside, the clinical effect becomes noticeable after two hours, its peak reaches four hours, lasts up to 12 hours. To achieve the desired therapeutic effect, it have to be used at least one month, then the results are simply maintained at the proper level. Active components of the drug are perfectly absorbed by the gastrointestinal tract, the meal does not have a significant effect on this process. Almost 95% of the drug product is excreted unchanged by the kidneys, not metabolized in the liver.

The drug is used to solve such problems:

• treatment of hypertension (patients who are shown combined therapy of the disease);

• to prevent the risk of heart disease, mortality among patients with hypertrophy and left ventricular hypertension.

Hyzaar medication is contraindicated for use in the following cases:

• the presence of hyperkalemia;

• with anuria;

• pronounced serious pathologies of the kidneys and liver;

• arterial hypotension;

• presence in the patient's history of a lactase deficiency;

• dehydration with diuretics in high doses;

• children under 18 years of age (no clinical trials have been conducted, no efficacy or danger has been shown to young patients);

• periods of bearing of the baby, breast-feeding;

• increased sensitivity to active or auxiliary components of the drug;

• malabsorption syndrome of galactose or glucose.

It is used in conjunction with other antihypertensive agents. Tablets are recommended to be swallowed whole, washed down with a small amount of water. Food intake does not affect the effectiveness of the drug. Medication is not indicated for admission in the initial stages of the development of the disease, it is used in cases where drugs containing only one component of the drug cannot cope with the task.

Before the start of the medication, the level of sodium, the amount of fluid in the body is compulsorily studied. Doctors recommend taking the medicine at the same time, not missing a single pill.

In each case, the doctor chooses the individual dosage of the medication. The initial dose for all patients is one pill per day with a concentration of active substances (50 mg / 12.5 mg). If necessary, the dosage is increased until one tablet is taken 100 mg / 25 mg. The maximum dose is also one pill with the highest concentration of active ingredients per day.

It does not combine with fluconazole. Simultaneous admission with diuretics, which have a potassium-preserving effect, can lead to hyperkalemia. Nonsteroidal anti-inflammatory drugs reduce the effectiveness of active components of the drug. Patients with serious diseases of the kidneys and liver with the use of Hyzaar can significantly worsen their condition.

Simultaneous use with other antihypertensive drugs has a pronounced effect. Avoid high doses, the risk of overdose is high. Combination with diuretics can distort the performance of some components of the blood. Unpleasant reactions from various organs or human systems appear after prolonged misuse of Hyzaar. Read instruction before the therapy if you buy Generic Hyzaar online.

With special care, strict compliance with the doctor's instructions, the medication is used in the following situations: in diabetes mellitus, violations of water-electrolyte balance in the patient's blood, serious allergic reactions in a person's history, bronchial asthma or systemic ailments of the patient's blood.

There are no data on the use of Hyzaar during pregnancy.

Hyzaar side effects are observed in patients with increased sensitivity to individual components of the drug.

The list of possible negative reactions to the patient's preparation:

• infrequent dizziness, headache, sometimes it comes to migraine;

• tachycardia, vasculitis, palpitations;

• diarrhea, constipation, and abdominal pain often occur. Seldom there is a hepatitis, infringements in job of a liver (considerably rising of a level of a bilirubin);

• infrequent respiratory problems: infectious ailments of the upper respiratory tract, cough, edema of the nasal mucosa;

• sometimes there are pains in the muscles, back (lumbar region);

• anemia, significant changes in blood counts are rare among side effects;

• allergic reactions occur sometimes, in most cases, urticaria, skin itching, rash. Rarely is the edema of Quincke, which includes swelling of the tongue and larynx. Without proper medical attention, a lethal outcome is possible.

In exceptional cases, patients complain of general malaise, weakness, insomnia. Doctors do not recommend fighting with unpleasant symptoms. Address to the expert, probably, this medicine to you does not approach, the doctor will pick up necessary medical product.

Drug should be stored in a cool and dark place, the maximum permissible temperature is 30 degrees C. The shelf life of the medicinal product is not more than two years. If you want to buy Hyzaar without prescription then you can find it in Japan online pharmacy.