It is one of the few drugs that affect the regulation of blood pressure with minimal impact on cardiac activity. This drug has become the best among same group due to the safe and the mildest effect on the body of patients suffering from hypertension on the background of serious heart diseases, in which the most popular antihypertensive drugs cannot be used.
The active substance Irbesartan has a powerful hypotensive effect, affecting the receptors of angiotensin type 2, which are responsible for the contractility of the vascular walls. Angiotensin II is a special enzyme that, when in contact with them, causes narrowing of the lumen of the arteries, resulting in increased blood pressure.
The main feature of the drug is the lack of interaction with other enzymes, their metabolites and receptors. As a result of taking the medicine, there is no change in the blood picture, namely, an increase in the potassium concentration in the plasma, as well as a number of other people negative for people with cardiovascular diseases.
A sustained therapeutic effect occurs on average 14 days after the start of Avapro, but the maximum treatment results are observed after a month of regular drug intake. After the abrupt withdrawal of the drug, withdrawal syndrome is not observed, and arterial pressure gradually returns to the initial (available before the start of therapy) position.
Despite the very delicate effect, Avapro is considered one of the most powerful drugs that can significantly reduce the systolic and diastolic pressure. The drug under special conditions can provoke an exacerbation of existing diseases, or cause the beginning of new pathological processes of the body. That is why, when appointing a doctor, you should make sure that there are no clear contraindications, and also take into account all available indications and risks, which are directly or indirectly mentioned in the instructions for use. It is important to know about possible problems and patients who are prescribed this remedy.
In what kind of disease treatment Avapro is helpful?
Use of Avapro is recommended for essential-type hypertension, as well as in combination with other drugs in cases of arterial hypertension and diabetes mellitus nephropathy. With these two diseases, the drug shows maximum effectiveness with minimal manifestation of Avapro side effects and undesirable reactions.
What should I tell my health care provider before I take Generic Avapro?
The significant contraindications for tablets are the following:
• intolerance of components, both active and supplementary;
• lactation;
• pregnancy;
• childhood.
In addition, the tablets are cautiously prescribed for stenosis of the aortic or mitral valve, dehydration of the body, increased concentration of sodium in the blood plasma, severe heart failure and other pathologies of the heart, coronary and renal arteries. Very important is to read carefully the instruction, especially if you buy Generic Avapro online.
How should I take Avapro?
Applying the drug on the basis of the presence of a single dosage form can only be carried out orally - without crushing the tablet before or just during it.
Dosage information
The optimal initial dosage is 150 mg per day, that is, one tablet at the appropriate dosage once a day, regardless of food intake. At the same time, in the first 2-3 days, blood pressure measurements should be made twice or thrice a day for the timely detection of excessive decrease in indices or the ineffectiveness of the dose taken.
If therapy is ineffective by taking 150 mg of drug per day, Avapro dosage should be increased to 300 mg. In addition, the doctor may consider the appointment of additional medications - diuretics, which enhance the effectiveness of Avapro.
With the diagnosis of nephropathy, the initial dosage, regardless of blood pressure, is 150 mg. Within 2-3 weeks it is gradually increased to the maximum possible, that is, up to 300 mg per day. It is this dosage that is considered the most effective for supporting treatment of patients with nephropathy.
It is recommended to lower the dosage to patients in old age and to persons who are forced to undergo regular hemodialysis. For them, the optimal dose for starting therapy is 75 mg per day.
What may interact with Generic Avapro?
The main substance actively interacts with other medications. And it does not always pass unnoticed, because in some cases such reactions lead to the appearance of a variety of negative changes. That is why, when prescribing the drug, the doctor must take into account the probability of influence on the assimilation and effectiveness of Irbesartan of other chemical compounds.
When Avapro medication is used in combination with other means for lowering blood pressure, strengthening the hypotensive effect becomes inevitable. However, there are no critical "falls" in the systolic and diastolic scales, especially if the dosage was initially calculated taking into account the fact that the therapy will be comprehensive.
With simultaneous admission with potassium-sparing diuretics, heparin and potassium preparations, the drug can cause a change in the blood picture due to an increase in the concentration of potassium in the blood plasma. The same can happen when taking medication simultaneously with lithium preparations. In order to avoid toxic effects of the latter, during therapy, it is necessary to maintain a constant monitoring of the concentration of lithium in the blood plasma.
Preparations related to NSAIDs taken at the same time may reduce the effectiveness of the latter. To avoid this, it is necessary to refuse to use them together, or to revise the dosage of an antihypertensive drug. The latter option is not always possible, especially if patients have kidney problems or are elderly (over 60). The combination with NSAIDs can lead to the development of acute renal failure.
What should I watch for while taking Avapro?
It can cause the appearance of undesirable changes in the functioning of the body, the frequency of occurrence of which does not depend on sex, age or other factors.
It is important to interrupt the treatment of hypertension before conception of a child is achieved. At the onset of pregnancy, it is recommended to stop taking the tablets in a very short time.
The same recommendations are relevant for women during the breastfeeding period. In case of acute need for Avapro drug it is recommended to transfer the child to artificial feeding.
What side effects may I notice from Avapro?
Most often, patients who undergo Avapro therapy have the following side effects:
• dizziness or headache;
• indigestion, heartburn and diarrhea;
• tachycardia and other changes in the heart rate;
• coughing or difficulty breathing;
• pain in the muscles of the legs and back;
• redness of the skin, allergic rash, itching and swelling.
In isolated cases, patients noted deterioration of erectile function and decreased libido, a change in perception of taste or taste perversion.
Where can I keep Avapro?
When storing tablets, it is not recommended to allow excessive (above +30 degrees C) air heating in the room, as well as direct sunlight and moisture on the medicine. If these conditions are met, the drug retains therapeutic properties for at least three years. Also it is possible to buy Avapro without prescription in different international pharmacies like Italy online pharmacy.
