Vaseretic (Enalapril-hydrochlorothiazide)

70% of patients with hypertension experience the need for combined treatment. The main reasons are insufficient monotherapy effectiveness and low adherence of patients to treatment, which is associated with side effects. Fixed combinations of low-dose antihypertensive components are a full-fledged replacement of 2-3 medications, which allows you to follow the recommendations of the doctor, provides a reduction in the pharmacological load, minimizes the likelihood of side effects, improves the tolerability of pharmacotherapy, and reduces the cost of treatment.

One such drug is Vaseretic. The drug is recommended for use also with pathologies of the heart muscle, it is very important to strictly follow the dosage. The medication allows you to quickly get rid of the symptoms of hypertension, the ignoring of which can lead to death.

The effect of the drug is due to its constituent components, it has an antihypertensive effect. A diuretic with an average strength of action hydrochlorothiazide ensures the elimination of bicarbonate, water, Na +, Cl- from the body. Reducing the content of Na ions in the vessels ensures their dilatation; as a result, sensitivity to vasoconstrictor factors decreases.

Hydrochlorothiazide provides a decrease in plasma K +, enalapril provokes its delay. Simultaneous reception of these drugs provides normal maintenance of the K + content in the plasma. Hydrochlorothiazide helps normalize the excretion of phosphates and hydrocarbons. The substance does not adversely affect the brain and kidneys, which indicates the safety of the drug for vital systems and organs.

Under the influence of enalapril, ACE inhibition is provided, which facilitates the transformation of angiotensin I into angiotensin II. As a result of taking the drug, the aldosterone content in the plasma decreases, the release of renin, Pg and endothelial relaxing factor of the veins increases, sympathetic nervous system depression is observed, and the kallikrein-kinin vasodepressive system is improved.

The combination of these factors contributes to the elimination of spasms, reduced OPSS, diastolic and systolic blood pressure, post-and preload on the myocardium, and the peripheral arteries also expand. The effect of expanding the arteries is not accompanied by an active increase in heart rate, as happens at the reflex level.

The main indication is hypertension, Vaseretic drug is also recommended for use in heart failure of any degree. The medication is also indicated to reduce the risk of unstable angina and myocardial infarction.

Taking the medicine is prohibited in the following cases:

• anuria;

• age to eighteen years;

• stenosis of the renal arteries;

• allergic reactions, intolerance and lactose deficiency;

• history of swelling caused by taking ACE inhibitors;

• impaired renal function;

• hypersensitivity to components.

• pregnancy or breast-feeding;

• age under 18 years;

• high sensitivity to the components of the drug.

Caution should be observed in the following cases:

• cerebrovascular pathologies;

• insufficient blood circulation of the brain;

• IHD;

• idiopathic stenosis;

• stenosis of the aorta.

Vaseretic is also not recommended for permanently elevated blood pressure or diseases that cause it because it can lead to autoimmune pathologies of connective tissue, atherosclerosis, stroke, heart failure, heart attack.

Tablets should be taken without chewing, regardless of food intake.

The starting dosage should not exceed 5 mg per day, there is a gradual increase in the dose to 20 mg, sometimes up to 40 mg, twice a medication is prescribed.

In cardiac decompensation, a significant reduction in blood pressure can be observed. For this reason, small doses are taken under the supervision of a doctor.

If the patient has been treated with diuretic drugs, taking Vaseretic can trigger a decrease in the volume of circulating blood and cause the development of arterial hypotension. In such a situation, the starting dose is reduced to less than 5 mg / day. When treating a child, the dose is calculated taking into account its body weight, if it is less than 20-50 kg, the dose should not exceed 2.5 mg. If you buy Generic Vaseretic online then to read about suitable for you dosage you can in instruction which you can find in package.

Vaseretic medication enters into the following drug interactions:

• Potassium in its pure form, potassium supplements, potassium-saving drugs - a sharp drop in potassium content in the blood serum (especially in kidney failure, kidney pathology);

• Lithium prepolite - reducing its excretion, which has a negative effect on the functioning of many systems;

• Thiazide diuretics - enhance the effect of removing chloride;

• Opioid analgesics and drugs, which include phenothiazine - the development of orthostatic hypotension;

• Calcium channel blockers, alpha and beta adrenoblockers - an additional reduction in blood pressure during treatment;

• Colestyramine - a decrease in the absorption of the drug by 85%;

• Allopurinol and immunosuppressants - increased risk of developing leukopenia;

• Thiazide diuretics together with GCS - promotes the development of hypokalemia,

Ignoring the compatibility of drugs can provoke flushing of the face, arterial hypotension, severe vomiting. If these abnormalities are detected, it is recommended that you seek medical attention.

During pregnancy, taking Vaseretic is prohibited.

Failure to follow instructions can cause the following side effects:

• Disturbances and pathologies of the hematopoiesis system, reduction of hemoglobin, oppression of the bone marrow, and leukopenia.

• Diseases of the central nervous system a strong cough, shortness of breath, increased excitability, insomnia / drowsiness, headache, tinnitus, constant dizziness.

• Diseases of the cardiovascular system, hypotension, pain in the chest, syncope, tachycardia.

• Disorders of the functioning of the gastrointestinal tract, a feeling of dry mouth, abdominal pain, diarrhea, vomiting, nausea.

• Genitourinary system impotence, decreased libido.

In the presence of one or more symptoms, a doctor is recommended, who after the tests will prescribe the treatment.

Drug is recommended to store at a temperature of no higher than 30 degrees for five years from the date of production. You can also buy Vaseretic without prescription in international pharmacies like USA online pharmacy.