Plendil acts on the body as an anti-anginal and hypotensive agent, slows the flow of calcium ions into the smooth muscles of blood vessels, lowers blood pressure, and strengthens coronary and renal blood flow. Depending on the dose taken, the anti-ischemic effect may be. Today, many people have taken the rule before committing an expensive purchase to go for advice on the Internet. Medicines are not the exception. Potential buyers are interested in indications and contraindications to the use of the prescribed drug, the side effects that it causes. Of course, the question of possible analogs, as well as, finally, the feedback of doctors and patients who have already tested the prescribed remedy is also important. This time, we collected under one heading the answers to the most common patient questions about the Plendil drug manufactured by Astrazeneca Pharma.
It is used in therapeutic doses, the drug has no effect on conduction and contractility of the heart muscle, is selectively active against smooth muscle cells of arterioles. Plendil has a weak natriuretic and diuretic effect; the drug does not provoke fluid stagnation in the body. It begins to "work" 2-5 hours after admission, the drug is active for a day, while completely absorbed from the gastrointestinal tract and then metabolized in the liver. You can choose a replacement for drug Plendil. And analogues can be searched both among medicinal products, and in the number of homeopathic remedies. Dosage and method of taking analogs should also be prescribed exclusively by a doctor. Remember that self-medication can not only aggravate your health even more, but also cost you life!
In what kind of disease treatment Plendil is helpful?
Indications for use are angina pectoris, arterial hypertension, and Raynaud's syndrome. In the case of the latter, the drug is taken for symptomatic treatment.
What should I tell my health care provider before I take Generic Plendil?
The drug is not prescribed for people with tachycardia and hypotension, expressed by renal, hepatic and cardiac insufficiency, unstable angina, and hypersensitivity to dihydropyridine derivatives.
Postponed vascular and cardiogenic shock, acute infarction (in particular the first week after the attack) are also contraindications to the use of Plendil. In addition, it is not prescribed for pregnant women, women during lactation and children (until they reach 18 years of age). Also it is very important to read the instruction if you prefer to buy Generic Plendil online to avoid undesirable consequences.
How should I take Plendil?
Doctors advise taking pills in the morning, washing them with water (there is no need to broke pills or chew them). It does not matter whether the drug is taken before breakfast or after it. The only thing that doctors advise breakfast should not be oversaturated with fatty, "heavy" products.
Dosage information
It should be remembered that only the attending physician can prescribe this remedy! He also selects the dose individually for each patient. Usually therapy is started with 5 milligrams a day (for patients of advanced age with 2.5 mg). If there are medical indications for this, the dosage can be increased to 10 mg, but it cannot exceed 20 milligrams in 24 hours.
What may interact with Generic Plendil?
1. Simultaneous use of Plendil and such drugs as "Cimetidine", "Erythromycin", "Ketoconazole" (acting as inhibitors of cytochrome P450), increasing the content of felodipine in the plasma.
2. Reducing the same level of felodipine in blood plasma is promoted by the combination of the drug with barbiturates, phenytoin and carbamazepine.
3. With caution should also be taken to the simultaneous reception of Plendil drug and drugs containing beta-blockers: this compound significantly increases the chances of developing chronic heart failure.
4. It is interesting that not only drugs can interact with Plendil it has been established that concentrated grapefruit and grapefruit juices, due to the presence of flavonoids in them, increases the bioavailability of felodipine almost threefold.
What should I watch for while taking Plendil?
During treatment with Plendil, extreme care should be taken when performing work that requires high concentration and rapid reaction. Stop treatment is better not abruptly abolishing the drug, but gradually reducing its dose.
1. During the selection of dosage, it is necessary to control blood pressure and heart rate.
2. Care is taken when driving. During the period of therapy, it is necessary to refrain from potentially dangerous activity, which may require increased attention and rapid reaction.
3. Patients with angina should explain that the drug often causes an arterial hypotension, leading to myocardial ischemia or worsening it.
4. Parallel application with grapefruit juice is unacceptable - the juice contains flavonoids, which can increase the concentration of the drug in the blood.
What side effects may I notice from Generic Plendil?
Usually the drug does not give tangible Plendil side effects. However, with increased sensitivity to components (in particular to felodipine), patients can experience headaches, dizziness, palpitations, weakness, nausea.
In more rare cases, taking pills can trigger the appearance of an allergic rash, heat, swelling, vomiting, and depression. In case of an overdose of the drug, hepatitis, gingival hyperplasia, anemia, visual impairment, severe hypotension, bradycardia are possible.
Rarely:
• extrasystole,
• a pronounced and persistent decrease in pressure,
• leukocytoclastic vasculitis,
• angioedema of the tongue or lips,
• frequent urination,
• hyperglycemia,
• fever,
• increased activity of hepatic transaminases.
Where can I keep Plendil?
If the temperature is maintained properly (not above 75 F), medication can be stored for up to 36 months. It should be out of reach for children. It is possible also to buy Plendil without prescription in different international online pharmacies, for example, Italy online pharmacy.
