Arterial hypertension is a disease characteristic of the elderly. To keep blood pressure under control, patients are prescribed special drugs with antihypertensive action. Among these drugs is Lozol SR - a drug based on indapamide. A similar drug is Lozol with the same main substance. It is an antihypertensive agent (vasodilator, diuretic). It is close to thiazide diuretics for its pharmacological properties, increases the excretion of sodium, chlorine (more), magnesium and potassium (to a lesser extent) in the urine.
It has the ability to selectively block "melted" calcium channels, reduces OPSS, makes the artery walls more elastic, and reduces hypertrophy of the left ventricle. Carbohydrate metabolism and plasma lipid content are not affected. Stimulates the synthesis of prostacyclin PgI2 and PgE2, makes the vascular wall less sensitive to angiotensin II and noradrenaline, and reduces the production of stable and free oxygen radicals. The administration of the drug in high doses does not affect the degree of depression of blood pressure.
Therapeutic effect after repeated administration is noted after one to two weeks, it becomes maximal after 2-3 months, and it persists for eight weeks. The maximum effect after a single dose can be achieved after 24 hours.
A small tablet contains a diuretic substance, the main functions of which are: a decrease in the tension of the smooth muscles of the vessels, an increase in the formation of prostaglandins (lipid substances that dilate the vessels), and a decrease in the left ventricle of the heart.
In what kind of disease treatment Lozol SR is helpful?
The medicine is prescribed for people with arterial hypertension. Other indication for the purpose of the drug:
1. Development of hypertensive diseases of moderate severity.
2. Heart failure of chronic form.
What should I tell my health care provider before I take Generic Lozol SR?
There are several cases in which Generic Lozol SR should be administered cautiously and only when other drugs do not give the desired result. These include the following:
•Impairment of the kidneys.
•Violation of the normal functioning of the liver.
•Violation of the water-salt balance in the body.
•Development of hyperparathyroidism.
•With a noticeable increase in the QT interval, which can be seen on the ECG.
•Diabetes mellitus, developing at the stage of decompensation.
•Symptoms of hyperuricemia, which is often accompanied by diseases such as nephrolithiasis of urate type or gout.
Also it is important to read the instruction if you buy Generic Lozol SR without prescription.
How should I take Lozol SR?
In oral intake patients should not chew the tablet. It is preferably to take it in the morning.
Dosage information
The drug is taken in an initial dose - once a day for 1,25-2,5 mg. If the desired effect cannot be achieved with this dose, after four to eight weeks of therapy, a drug with a different mechanism of action can be added. Doctors do not recommend increasing the Lozol SR dose: this leads to an increase in unwanted reactions in the absence of an increase in the effect.
What may interact with Generic Lozol SR?
Combined use with lithium preparations promotes an increase in the plasma concentration of lithium ions. Combined use of Lozol SR with iodine-containing contrasting drugs is fraught with impaired renal function. Before the appointment of iodine-containing contrasting drugs, the patient should perform a correction of the BCC.
The drug enhances the effect of nondepolarizing muscle relaxants, reduces the effectiveness of indirect anticoagulants (derivatives of indandion or coumarin). Increased risk of hypokalemia in the use of Lozol SR in combination with cardiac glycosides, mineralocorticoids, amphotericin B (IV), diuretics thiazide and "loop", laxatives, glucocorticosteroids, tetracosactide. When combined with metformin, aggravation of acidosis of lactic acid is possible; with calcium preparations - the development of hypercalcemia, with cardiac glycosides - digitalis intoxication. Erythromycin (IV), sultopride, astemizole, pentamidine, vincamine, terfenadine, antiarrhythmic drugs of class III and IA are able to increase the probability of arrhythmia development "pirouette".
Use with angiotensin-converting enzyme inhibitors increases the likelihood of developing renal failure with acute and / or orthostatic hypotension. NSAIDs, tetracosactide, glucocorticosteroids and adrenostimulants help reduce the hypotensive effect of Lozol SR, and baclofen - to enhance it. The risk of hypercreatininemia increases cyclosporine. Antipsychotic drugs and imipramine (tricyclic) antidepressants enhance the action of Lozol SR, increase the likelihood of orthostatic hypotension.
What should I watch for while taking Lozol SR?
Lozol SR only in some cases is the cause of the patient's various undesirable reactions. Such phenomena, as a rule, are explained by the fact that the body does not take the chemicals that make up this medication.
What side effects may I notice from Generic Lozol SR?
As a result of a significant excess of the recommended dose of the drug, an overdose is possible. It is accompanied by several Lozol SR side effects:
1. The appearance of general weakness.
2. Attacks of nausea.
3. Explicitly expressed disruption of the gastrointestinal tract.
4. Violation of the water-salt balance in the body.
5. A sharp decrease in blood pressure.
6. Difficulty breathing.
7. The development of hepatic coma symptoms is sometimes observed in patients who suffer from cirrhosis of the liver.
To treat the consequences of an overdose of drug Lozol SR, you must first thoroughly wash the stomach, and then conduct a special recovery of the water-electrolyte balance.
Where can I keep Lozol SR?
To store the medicine you need to pick up a dry and well ventilated place, inaccessible to children. Also it must be reliably protected from direct sunlight. The most optimal air temperature is 25 ° C. You can also buy Lozol SR online in different pharmacies such as Italy online pharmacy.
