It suppresses abnormal neuronal activity without inhibiting their function. Lamotrigine is its active ingredient. Lamotrigine is its active ingredient.
Lamictal is actively used as a drug that reduces the pathological activity of neurons as well as provides the oppression of their functions. Preparation performs stabilizing of neuronal membranes by exposure to Na+ channels blocking of excess release of amino acids with excitatory function wherein the drug does not disturb the normal course of glutamate release.
Lamictal can be prescribed to adult patients and children suffering from epileptic seizures. This can be a monotherapy or combination therapy in conjunction with other drugs of the same group.
It is absorbed from the gastrointestinal tract quickly. The plasma maximal concentration is fixed after 2.5 hours after taking; after the meal significantly increases the time to reach it.
In what kind of disease treatmentLamictal is helpful?
The result of taking this drug is the reduction or complete removal of epileptic seizures.
It gets best reviews when it is used in the treatment of the following diseases:
partial or generalized seizures;
epilepsy;
for patients less than 2 years the use of funds is only allowed in different combinations;
bipolar disorders (18 years of age and older; prevention of mood disorders, mixed episodes, hypomania, mania, depression).
What should I tell my health care provider before I takeGeneric Lamictal?
It is forbidden to use in the detection of the following contraindications:
Individual intolerance of components;
Hypersensitivity;
Lactation;
Pregnancy;
Up to 18 years.
Carefully:
In case of renal insufficiency.
How should I take Lamictal?
The tablets are taken orally, swallowing whole without chewing and without breaking. Eating has almost no effect on the level of absorption.
The scheme of treatment duration and dosage are set highly individual for medical prescriptions on the basis of clinical indications. This drug the patient takes twice a day.
Dosage information
In epilepsy in adult daily dose during the first couple of weeks is 25 mg in one portion. The next two weeks dose increases to 50 mg. It may be increased to obtain the desired effect. The optimum daily dosage is 100-200 mg per day. The dose should be reduced in the case of simultaneously receiving Lamictal and Valproate. In this case, the medication is divided into two. If during treatment the patient is prescribed drugs that activate hepatic enzymes the starting daily dosage is 50 mg and then it increases every two weeks by 50 mg. Basically the desired therapeutic effect is obtained when taking Lamictal dose of 200-400 mg per day for a couple of consumptions.
The starting daily dose for children between 2 and 12 years in conjunction with Valproate and other anticonvulsants is 0.15 mg per 1 kg. Is possible the increase of the dosage to 0.3 mg per day to achieve the desired effect. The optimal dose is 1-1.5 mg per kg.
When taking Lamictal and other drugs with activation of hepatic enzymes daily dose is 0.6 mg per kg body weight for a couple of weeks, for next few weeks it is 1.2 mg per kg body weight.
What may interact with Lamictal?
Interactions:
• Accelerate of metabolism of Lamotrigine and halving of the period of the collapse of half of all atoms with Paracetamol, Primidone, Carbamazepine, Phenytoin and others;
• The interaction with hormone replacement therapy and oral contraceptives have not been studied;
• Antiepileptic drugs that contain Lamotrigine is contraindicated without consultation of the physician.
What should I watch for while taking Lamictal?
Be aware that an overdose of this drug needs hospitalization and gastric lavage.
To avoid symptoms of side effects and achieve maximum effectiveness in the treatment of drug, it is necessary to strictly adhere to the dosage and course of treatment prescribed by the attending specialist.
Dose adjustment downwards may be required only at a significantly reduced renal function.
Increased dosage as a maintenance dose, are adjusted from the observed clinical effect.
Lamictal can be taken in the period of lactation and pregnancy but only by indications the physician and with the analysis of benefits and harm to the mother and fetus.
Consumption should be discontinued if there are no obvious causes of fever and lymphadenopathy and to provide the patient an immediate thorough examination.
Skin rash is a possible symptom of hypersensitivity, in rare cases of its severity it may lead to thrombus syndrome and the development of multiple organ failure. In most cases skin rash expressed slightly, as a rule it pass on its own; doesn’t have dose-dependent effect.
Abolition should be made gradually by reducing the dose during two weeks except in cases of urgent discontinuation of therapy including the appearance of skin rash. Therefore to break the treatment scheme and to exceed the recommended dosing regimen is not allowed because of the likelihood of development of skin rash.
You should refrain from driving and controlling complex mechanisms because of the high probability of side effects such as dizziness and so on.
What side effects may I notice from Generic Lamictal?
Is possible a manifestation of a number of side effects:
hypersomnia;
insomnia;
confusion;
fatigue;
tremors;
increased aggression;
leukopenia;
skin rashes;
nausea;
vomiting;
dizziness and head pain, mood swings, dullness of mind;
blurred vision, conjunctivitis;
swelling, anemia, fever, abnormal liver function.
As treatment it is recommended hospitalization and implementation of maintenance therapy.
Where can I keep Lamictal?
Lamictal drug is kept out of the reach of children in quite dark and dry place with temperature up to 30 ° C but not higher.
