Danocrine (Danazol)

What is Generic Danocrine?

Danocrine is a drug that actively suppresses the production of gonadotropins.

It does not have gestagenic and estrogenic activities. It is endowed with weak androgenic activity with anabolic effect. It inhibits proliferation and contributes to atrophy of ectopic endometrial tissue.

It reduces with its action the loss of menstrual blood but nowadays its action is not studied yet.

It suppresses ovulation and decreases in plasma levels of 17 beta -estradiol. Ovulation resumes after discontinuation of the drug in five weeks with increases of LH and recorded a slight increase of FSH.

Danazol is absorbed from the gastrointestinal tract and while eating it increases significantly and directly metabolized by the liver.

In what kind of disease treatment Danocrine is helpful?

The main indications of the drug are:

• Gynecomastia;
• Angioedema (prevent serious allergic reactions);
• Premenstrual syndrome;
• Menorrhagia;
• Endometriosis because of infertility factors;
• Benign neoplasm of breasts.

What should I tell my health care provider before I take Generic Danocrine?

Danocrine has contraindications:

• Hypersensitivity;
• CHF;
• Porphyria;
• Androgen dependent tumor;
• Carcinoma;
• Functional disorders of the kidney / liver;
• Thromboembolic disorders;
• Mammary cancer;
• Vaginal bleeding;
• Pregnancy;
• Lactation period;
• Children;
• Elderly age.

Extremely careful you should use it if you have the following diseases:

• Diseases of cardiovascular system, including hypertension;
• Diseases of the liver and / or kidney problems;
• A variety of diseases, escalating due to fluid retention;
• Diabetes;
• Epilepsy;
• Violation of lipid metabolism;
• Migraine;
• Hemostasis disorders;
• History of therapy with androgen reaction on sex hormones.

How should I take Danocrine?

It should be taken orally with liquid or food usually twice a day.

Dosage information

Danocrine is presented in the form of capsule; each contains 50, 100 and 200 mg of active ingredient. Dosage should be chosen individually by physician and for medical reasons, usually it is the minimum effective dose but the daily maximal is 800 mg.

What may interact with Danocrine?

During using Danocrine concurrently with other medicinal products are observed:

Strengthening action of indandiona derivatives and coumarin anticoagulants (increased chance of bleeding);

Weakening of efficacy of oral hypoglycemic agents and insulin (by acting on carbohydrate metabolism by increasing the glucose concentration in the blood);

An increase in plasma concentrations of glucagon, tacrolimus and cyclosporine increases the risk of nephrotoxicity;

Inhibition of metabolism of antiepileptic drugs and an increase in the blood concentration (phenobarbital, phenytoin and carbamazepine);

Also is possible hypercalcemia in combination with alfacalcidol in primary hypoparathyroidism.

What should I watch for while taking Danocrine?

The properties of Danocrine increase testosterone levels in blood and affect the result of sex hormones test.

Patients with diabetes need correction of doses of insulin during the treatment. It is not recommended for elderly people.

Before the therapy women of childbearing age need to verify the absence of pregnancy, treatment should begin immediately on the first day of menstruation and patients can use during taking drugs a non-hormonal contraception.

It is allowed the use Danocrine for the treatment of children with early puberty.

What side effects may I notice from Generic Danocrine?

It can cause possible side effects:

Endocrine:

• Nervousness;
• Reduced size of the breasts;
• Inflow of blood to the face;
• Vaginitis;
• Amenorrhea;
• Changes in libido;
• Increased sweating;
• Swelling;
• Deepening of the voice;
• Weight gain;
• Violation of spermatogenesis.

Digestive System:

• Elevated liver enzymes;
• Functional gastrointestinal disorders.

CNS:

• Depression;
• Dizziness;
• Tremors;
• Headache;
• Sleep disorder;
• Weakness.

Other:

• Insignificant increase in intracranial pressure;
• Cholestatic jaundice;
• Blurred vision.

Systems of blood:

• Reduction / increase in the number of blood cells.

Metabolism:

• Impaired glucose tolerance.

Where can I keep Danocrine?

Keep the drug in a dark and dry, inaccessible to children place at twenty five degrees. If you have prescription you can buy this drug at your local pharmacy or you can buy Danocrine online without prescription.