Cordarone (Amiodarone)

It is an antiarrhythmic drug of the 3rd class, which has antiarrhythmic and antianginal effect:

• the drug is able to block a- / b-adrenergic receptors;

• slows atrial, sinoatrial and nodal conduction, without affecting the intraventricular;

• increases the refractory period of additional ventricular and atrial pathways;

• does not have a negative inotropic effect;

• reduces the contractility of the heart muscle after intravenous administration;

• affects the metabolic processes of thyroid hormones;

• inhibits the transition of hormones T3 to T4 and blocks their capture by cardiocytes and hepatocytes, which weakens the stimulation of thyroid hormones on the myocardium.

In blood plasma, it can be determined for nine months after the reception was stopped. The therapeutic effect can be observed 1 week after the beginning of oral administration.

When administered intravenously, Cordarone medication reaches its maximum level 15 minutes after administration and disappears after 4 hours. Despite a short period of excretion of the drug from the body, complete saturation of the tissues is achieved. If there is no repetition of injections, the drug is withdrawn gradually. And when you resume - the tissue stock is formed. Many patients say that it is a wonderful drug that really restores the rhythm of the heart. But too long and uncontrolled use of it which can lead to the removal of the thyroid gland. The rhythm breaks down sometimes, but for many people it is the only drug that brings them to life.

The drug is used in the following cases for arresting an attack:

• paroxysmal form of tachycardia, ventricular and supraventricular with frequent contractionof the ventricles; 

• paroxysmal atrial fibrillation and its stable form (atrial fibrillation and flutter).

With the help of drug Cordarone they also carry out the prevention of relapses:

• life-threatening ventricular arrhythmia and ventricular fibrillation;

• paroxysmal supraventricular tachycardias, including documented seizures in organic heart diseases;

• documented attacks of persistent paroxysmal supraventricular tachycardia without organic heart disease in the case of ineffectiveness of previously used antiarrhythmic drugs or with contraindications;

• documented recurrent seizures of persistent paroxysmal supraventricular tachycardia with WPW syndrome;

• arrhythmias of atrial fibrillation and flutter.

It is recommended especially for patients with organic heart diseases with ventricular dysfunction, including cardiac ischemia.

Inform your doctor about the following conditions:

• hypersensitivity to amiodarone and iodine;

• syndrome of the weak sinus node (bradycardia sinusovaja, sinoatrial blockade), exception - cases of correction of the artificial driver of a rhythm;

• violation of atrioventricular and intraventricular conductivities;

• combination with drugs that can cause a ventricular polymorphic tachycardia such as "pirouette";

• thyroid dysfunction (hypothyroidism or hypertension);

• heart failure, hypokalemia;

• pregnancy, the period of breastfeeding;

• age less than 18 years (safety not established);

• simultaneous administration of MAO inhibitors;

• interstitial lung diseases.

Take this medication internally and wash it down with enough amount of liquid.

Dose load:

• Inpatient: the initial dose, divided into several doses, should be from 600-800 mg (maximum = 1200 mg) on the 1 day before the total dose of 10 g (usually 5-8 days).

• Outpatient: The initial dose, divided into several doses, should be about 600-800 mg per day up to a total dose of 10 g (usually 10-14 days).

• Maintenance dose: 3 mg per kilogram of body weight per day. It can be within even from 100-400 mg per day with a one-time admission. It is recommended to apply the minimum effective dose, based on individual therapeutic results.

The form in the injectable form is intended for use to achieve an antiarrhythmic effect and when it is not possible it is used orally. It has a long half-life, in this regard, it can be taken every second day (200 mg every 2 days, and 100 mg daily is recommended). You can take breaks 2 times a week). The drug should be taken if recommended by a doctor. Read the instruction carefully if you buy Cordarone online.

To enhance the antianginal effect, it is recommended that the combination with nitrate preparations be prolonged. You can be prescribed the drug along with cardiotonic drugs (eg, digitalis), but there is a risk of developing a bradycardia.

Cordarone is prescribed together with diuretics and anticoagulants. There are no known cases of interaction with droperidol, chloroprotexen, phenoperidone, dextromoramide, pentobarbital and pancuronium bromide.

It is not recommended to take Verampil drugs and MAO inhibitors along with Cordarone. And also do not use it together with beta-blockers (exception - some severe cases with hemodynamic features).

If you take medication Cordarone for a long period before surgery, there will be no adverse effect on resuscitation and anesthesia.

Organs of vision:

• Deposition in the epithelium of the cornea lipofuscin;

• There are rarely complaints of "fog" before your eyes in very bright light.

Dermatological reactions:

• Sensitization, manifested as erythema in unopened areas of the skin;

• It is rare that small pigmentation occurs on unopened areas of the skin.

Endocrine status:

• Rarely with long-term prescription may develop hypothyroidism, very rarely - hyperthyroidism.

The cardiovascular system:

• At high doses of Cordarone, bradycardia may appear, AV conduction may be slowed, arterial hypotension.

The nervous system:

• Rare cases of development of peripheral neuropathy and tremor are possible.

Gastrointestinal tract and liver:

• Nausea;

• Heaviness in epigastrium;

• Impaired liver function.

Respiratory system:

• There were cases of pneumonitis and alveolitis.

When using parenteral, a feeling of heat, sweating, bronchospasm, in patients with severe heart failure may cause apnea, intracranial pressure may increase, local reaction - phlebitis.

Drug should be stored at room temperature, not exceeding 25 ° C. Store in the original box of cardboard, in a dry place, away from children. If you don’t have opportunity to buy medication in a regular pharmacy or you just want to buy Cordarone without prescription then you can find it in a Sweden online pharmacy.