Pharmacological action of this medication is antiviral. It inhibits protease, acts on HIV-1. 1 capsule contains indinavir sulfate 400 mg; in bottles of 30, 60 and 10 pills respectively. It combines well with all nucleoside reverse transcriptase inhibitors.
The pharmacological effect of this proteinase inhibitor is the ability to inactivate proteolytic enzymes, as well as prevent the release of various active polypeptides-for example, kinins. Against the background of their reception, inhibition of the processes of inflammatory swelling of tissues is also observed by rapid stabilization of capillary permeability. It is necessary to take into account the processes of activating the already existing human plasma inhibitor or the organ itself.
It is believed that NS3 / 4 protease inhibitors block the splitting of the viral protein into various structural components, and NS5B polymerase inhibitors disrupt the growth of viral RNA, which contributes to the destruction of the virus.
As a result of the action of drug, it does not fulfill its function, and viral particles that are not capable of infecting new cells are formed.
The main properties include:
• a significant reduction in pain impulses;
• relief of symptoms of general intoxication of the body;
• significant improvement in the patient's well-being;
• inhibition of the mechanism of tissue swelling transition in their necrosis on the background of hyperfermentation;
• anti-shock effect;
• lowering of exudation in serous cavities.
Complications after therapy are extremely rare, because the intravenous route of their administration does not allow creating the maximum concentration in the tissues of the pancreas
Despite the fact that the cost of original drugs reaches tens of thousands of dollars per course, relatively cheap analogs (generics) are available which, as a rule, are not inferior in effectiveness to the original, and the cost of which does not exceed $ 1000 for a standard 12-week course so you can easily buy Generic Crixivan online.
In what kind of disease treatment Crixivan is helpful?
Diseases caused by HIV-1 in adult patients who received or did not receive previous antiretroviral therapy (in combination with antiretroviral drugs or as monotherapy).
What should I tell my health care provider before I take Generic Crixivan?
Before start using this medication patients should consult with doctor, to get a diagnosis and a description to course of treating including your health state and medication that you currently take. The main contraindications are hypersensitivity and children's age.
How should I take Crixivan?
Do not combine pills with food for optimal absorption. It should be taken on an empty stomach, an hour before, or two hours after a meal, washed down with two glasses of water or other liquids (skimmed milk, juice, coffee, tea). When combined with didanosine, the interval between doses should be at least an hour.
Dosage information
A usual dose is 800 mg (2 capsules 400 mg) every 8h (2.4g / day). In combination with other antiretroviral agents (against the background of drug Crixivan, didanosine should be taken at intervals of at least 1 h). In combination with rifabutin appoint 1000 mg (3 capsules to 333 mg) every 8 hours; in combination with ketoconazole, itraconazole, efavirenz, a patient with hepatic insufficiency (cirrhosis) and with nephrolithiasis - 600 mg every 8 hours.
Usually it is used strengthened with ritonavir in three ways: twice daily 400 mg of indinavir + 400 mg of ritonavir; twice a day for 800 mg of indinavir + 100 mg or 200 mg. Currently, it is used extremely rarely, in view of the severity of side effects and the availability of alternative drugs.
What may interact with Generic Crixivan?
It is compatible with zidovudine, lamivudine, co-trimoxazole, fluconazole, isoniazid, clarithromycin, oral contraceptives. It is not recommended to appoint in combination with rifampin (can reduce the concentration of main substance in plasma), terfenadine, astemizole and cisapride (due to the suppression of their metabolism and the occurrence of cardiac arrhythmias).
What should I watch for while taking Crixivan?
It is recommended to drink at least 1.5 liters of liquid for 24 hours (to ensure adequate hydration). It is necessary to monitor the appearance of signs and symptoms of nephrolithiasis (pain in the side, hematuria).
During pregnancy, an appointment is possible if the potential positive effect justifies the possible risk to the fetus. At the time of reception lactating women should stop breastfeeding.
What side effects may I notice from Generic Crixivan?
Often there are the following Crixivan side effects on the gastrointestinal tract. With prolonged use, lipid metabolic disorders of varying severity and development of lipodystrophy are possible.
The most significant consequences are: stone formation in the kidneys (up to 25% of patients), less often - dry skin, mucous membranes, lipid disorders, dyspepsia.
Asthenia, fatigue,
insomnia, dry mouth,
perversion of taste,
abdominal pain,
heartburn,
nausea, vomiting,
flatulence,
diarrhea, dizziness,
headache,
lymphadenopathy,
decreased skin sensitivity,
nephrolithiasis,
increased ALT, AST,
indirect bilirubin and alkaline phosphatase in the serum and protein in the urine,
itching,
rashes.
Where can I keep Crixivan?
This medication does not require special storage conditions. It is advisable to keep the pills at a room temperature in a place far away from children, with low humidity, protected from sunlight. Do not use this medicinal product after the expired date. You can buy Crixivan without prescription in one of international online pharmacies, for example, in Turkey online pharmacy.
