It is a drug that is used in medicine in those cases where the patient is required to normalize the contractile activity of the heart muscle and increase the frequency of heart contractions. This medication is characterized by antiproliferative, as well as antioxidant effect. In addition, it provides a reliable adrenoblockade. Thanks to such properties, there is a significant increase in the effectiveness of the current course of treatment and the necessary therapeutic result is achieved. The drug is characterized by a linear relationship between the dose taken and the concentration in the blood. The drug Coreg is a highly lipophilic substance. About 99% of its composition binds to blood proteins. The half-period of the drug is 6-10 hours. In the liver, the process of metabolism of Coreg is due to the oxidation and glucuronization of the phenolic ring. After that, 3 metabolites are formed, which are characterized by beta-blocking properties. Elimination of the drug occurs with bile or calves. A small part is eliminated by the kidneys.
In what kind of disease treatment Coreg is helpful?
The drug is prescribed in the presence of such diseases as: Arterial hypertension; Stable angina; Chronic heart failure; Cardiac ischemia. As a result of taking this medication, the neurohumoral vasoconstrictor activation of the heart and vessels is suspended, the postload on the heart decreases, and the contractile function of the myocardium is gradually restored.
What should I tell my health care provider before I take Generic Coreg?
The drug should not be taken if the patient has the following conditions:
increased sensitivity to the main active ingredient or its absolute intolerance;
atrioventricular blockade of the first and second degree;
heart failure, which is in the stage of decompensation;
chronic lung diseases accompanied by a history of bronchial obstructive syndrome;
You should carefully read an instruction especially if you prefer to buy Coreg online.
How should I take Coreg?
It should be taken orally after eating, with a small amount of water. Dosage is determined by the cardiologist individually, depending on the degree and nature of the patient's disease.
Dosage information
It is very important during the therapy to exclude a possible arterial hypotension for this it is necessary to measure the pressure from the very beginning of the treatment one hour after each tablet intake. When the optimal therapeutic effect is achieved, in no case should the therapy be stopped abruptly-a decrease in the daily dose should occur gradually, for two to three weeks. For patients with essential hypertension, the recommended initial dose for the first two days of treatment is 12.5 mg once a day. In the future, the dosage should be increased to 25 mg per day. The maximum recommended dose is 50 mg, which should be taken in one or two doses. It should be noted that the dosage can be increased only with an interval of at least fourteen days. For patients who suffer from coronary heart disease, the physician prescribes the use of the drug at 12.5 mg twice the first two days of therapy the initial dose. Then the dosage is increased to 25 mg. The course of treatment of this disease involves the gradual adjustment of the dose to 100 mg with a dose divided by two. It is necessary to take into account the use of various other medicines in calculating the dose.
What may interact with Generic Coreg?
It is extremely undesirable to take it simultaneously with drugs that have antiarrhythmic effect, are intended for anesthesia, as well as for the treatment of angina and hypertension. In this case, adverse reactions of the body can develop. The effect of the drug may be enhanced by simultaneous administration with inhibitors of the isoenzyme CYP2D6, and decreased when taken with inducers of this isoenzyme. It is contraindicated with other drugs such as Verpamil and Diltiazem, intended for intravenous use, because in this case, the risk of developing severe forms of arterial hypotension increases. During a joint intake with insulin and oral medications with hypoklikemic effect, there is a danger of developing hypoglycemia. It is not recommended to take tablets and ergotamine derivatives at the same time, as this can worsen the peripheral circulation.
What should I watch for while taking Coreg?
For women during pregnancy using of Coreg is contraindicated. It is also not recommended to use this medication during breastfeeding this is due to the fact that the main active ingredient is able to penetrate the placental barrier and subsequently penetrate into the mother's milk. As a result, blockade of alpha and beta-adrenergic receptors in a baby can occur, which promotes the manifestation of a distress syndrome in the form of respiratory depression, bradycardia, as well as hypoglycemia and hypothermia.
What side effects may I notice from Generic Coreg?
In some cases, after taking pills, the following Coreg side effects may occur in patients: excessive decrease in blood pressure, which is episodic; headache, fatigue and general feeling of weakness; skin itching and exanthema of an allergic nature; urticaria; temporary nasal obstruction; lakopenia and thrombocytopenia.
Where can I keep Coreg?
The total shelf life of the tablets is 36 months. Store this product in a dry and well protected from light penetration, in conditions of air temperature not exceeding 25 C. You can buy Coreg without prescription in Netherlands online pharmacy.
