Clozaril (Clozapine)

The drug Clozaril belongs to the group of antipsychotic drugs. Based on positive reviews of patients, the drug creates an instant calming effect, and it has also proved to be an effective remedy for schizophrenia. In addition, it improves cognitive dysfunction.

The drug is available in the form of solutions for injection, tablets and granules intended for the preparation of suspensions taken orally (suitable for children). The main active substance is clozapine. The drug is a tool that has neuroleptic effects and has a sedative effect. The usual doses of the drug do not cause drowsiness, while the braking effect on the CNS is guaranteed. In addition, the product provides a calming effect on the CNS, so it can be used as a sedative.

The use of the drug helps to enhance the effect of taking sleeping pills and analgesic. In this case, the drug does not cause extrapyramidal disorders. The action is due to the blockade of dopamine receptors D2. The sedative effect is achieved by blockade of adrenoreceptors of the reticular formation of the brainstem. The drug is able to exert an antiemetic effect, which is possible due to blockade of dopamine D2 receptors in the trigger zone of the vomiting center. Hypothermic effect is achieved by blockade of dopamine receptors in the hypothalamus. Reception of this medication does not exert any influence on higher intellectual functions, and does not cause extrapyramidal disorders.

It is helpful in the treatment of the following diseases, as well as in the course of a number of diagnoses:

• schizophrenia (a disorder in the coherence of psychological processes, as well as a decline in mental activity), with a possible risk of suicide.

• behavioral or emotional disorder;

• sleep disorder;

• manic states;

• psychomotor agitation during the course of psychopathy.

Also the best reviews about Clozaril are obtained when it is used in the treatment of manic-depressive psychosis.

If symptoms of contraindications are found, use is strictly prohibited, as further use of it can lead to serious complications. Contraindications include:

• hypersensitivity to the active substance;

• impaired bone marrow function;

• pregnancy;

• ltion period;

• toxic psychosis;

• agranulocytosis or granulocytopenia in history.

Tablets are taken orally 2-3 times a day after eating.

The dosage of the drug should be selected individually by your doctor. At the very beginning of treatment, the amount of the drug should be minimal. Usually the initial amount of the drug should be 12.5 mg / 2 times on the first day, 25 - on the second day. In the future, the amount of medication should be increased daily, for 3 weeks, until it reaches 300 mg per day. To achieve the antipsychotic effect, the drug should be taken in an amount of 300-450 mg per day for several doses.

An antipsychotic result, most often, occurs when using a Clozaril dosage of 300-450 mg / day in several doses. The daily dose of the drug is allowed to be divided into unequal parts, but please note that the largest portion should be taken right before going to bed.

The maximum permissible dose of the drug Clozaril is 900 mg per day. When the dose is exceeded (from 450 mg per day), adverse reactions may occur. Read the instruction about the most suitable dosage for you if you buy Generic Clozaril online.

It is not compatible with alcohol, since the drug enhances the central effect of alcohol. Particular care should be taken when taking the drug simultaneously with psychotropic drugs, medications with antihypertensive and anticholinergic effect, depressing breathing.

Concomitantly with cimetidine or erythromycin it leads to an increase in the concentration of the drug in the blood and the development of consequences. Due to adrenolytic activity, weakens the hypertensive effect of norepinephrine. For the treatment of arterial hypotension, adrenaline is not recommended because of the danger of developing a paradoxical effect.

To avoid Clozaril side effects and achieve maximum effectiveness it is necessary to strictly adhere to the dosage and course of treatment prescribed by the treating specialist.

In the study of reproductive performance in animals, there were no signs of impaired fertility or a negative effect of clozapine on the fetus. However, the safety of Clozaril in pregnant women is not established, so the drug is prescribed only if the expected effect of treatment clearly exceeds the possible risk.

The main signs that you are overdone with the dosage of the drug will be:

• general drowsiness;

• confused consciousness;

• a sharp excitement;

• dilated pupils;

• sudden fluctuations of the heart;

• coma;

• lethargy;

• increased reaction;

• impaired breathing;

• dizziness;

• temperature increase;

• fainting;

• headache.

For the elimination of data by a symptom it is necessary to perform the following actions: to make a gastric lavage, to take enterosorbents, to perform cardiorespiratory intensive therapy, to control electrolytes, acid-base balance, symptomatic therapy.

Keep the pills inside the blister packaging. Expiration time of the tablets that have been unpacked may be significantly reduced. Keep this medication away from children. Do not store the medication in the washroom, on the window sills or in the vehicle. You can easily buy Clozaril without prescription in Canada online pharmacy.