Betapace belongs to the category of nonselective beta-blockers. The mechanism of drug exposure is based on the increase in the duration of action and the refractory period in all areas of the conduction of the cardiac system. The drug and its analogs provide a reduction in the frequency of contractions, as well as the contractility of the myocardium. Its action is accompanied by an increase in the tone of the muscles of the bronchi.
Betapace medication is a beta-blocker, it is prescribed to patients suffering from tachyarrhythmias, and the drug has selectivity for beta-1 / beta-2 receptors. The active ingredient is Sotalol hydrochloride. It has an overwhelming effect on the secretion of renin, the effect is expressed to a different degree under loads and in a calm state. When taking the drug in patients, there is a decrease in contractile activity and the frequency of myocardial contractions, and a decrease in the rate of atrioventricular conduction and a decrease in the absolute refractory period are also recorded. When drug Betapace is used, there is a decrease in the load on the heart muscle and with a decrease in its oxygen demand. The drug improves the tone of the smooth muscle layer of blood vessels and bronchi. 80-90% of the drug is excreted from the body through the kidneys, in elderly people with a normally functioning excretory system; the pharmacokinetics of the drug does not change.
In what kind of disease treatment Betapace is helpful?
Indications:
•accompanied by clinical symptoms of supraventricular tachyarrhythmias (including atrioventricular / paroxysmal / nodular tachycardia with paroxysmal atrial fibrillation of atrial reactions or WPW syndrome);
•normalization and maintenance of sinus rhythm after relief of flutter or atrial fibrillation;
•severe ventricular cardiac rhythm pathology, accompanied by a marked clinical symptomatology, as well as their prevention;
•arrhythmias caused by increased circulation of catecholamines or excessive sensitivity to them.
What should I tell my health care provider before I take Generic Betapace?
The drug has a large number of contraindications that is why you need carefully read an instruction especially if you buy Betapace online:
•intolerance of components;
•hypersensitivity to sulfonamides;
•heart failure of a chronic type at stage IIB-III;
•arterial hypotension, shock conditions;
•tachycardia of the form "pirouette";
•bradycardia;
•blockade of the sinus node and weakness syndrome;
•obliterating vascular pathology;
•respiratory diseases;
•metabolic acidosis;
•prolongation of the QT interval;
•edema of the larynx, allergic rhinitis in severe form;
•untreated pheochromocytoma;
•general anesthesia;
•age is less than eighteen years;
•2-3 degree of blockade of the atrioventricular node.
How should I take Betapace?
Tablets should be taken one to two hours before eating. At the initial stage of treatment, 1 tablet is given twice a day, with a periodicity of twelve hours. The dose, if necessary, can be increased after a clinical examination of the patient to 2 or 3 tablets per day.
Dosage information
The therapeutic effect in most cases is achieved with a daily dose of 1-2 tablets in two divided doses. Some categories of patients prescribe 3-4 tablets daily, taking such a dose is possible provided that the benefits of the drug exceed the risk and harm from Betapace side effects. The patient with a number of diseases the drug is shown to be taken only under steady-state conditions at the initial dose of one tablet. After a week, the daily dose is increased by half a tablet every next week.
The rate of dose increase is regulated depending on the patient's tolerability of the medication, which is assessed by the clinical response and the degree of induced bradycardia. For patients with impaired renal function, special conditions for taking the drug are provided, the Betapace dosage decreases when the serum creatinine reaches 120 mol / l.
What may interact with Generic Betapace?
Simultaneous use with antiarrhythmic drugs can lead to a pronounced expansion of the QRS complex and an increased risk of ventricular arrhythmia. Concurrent use with calcium channel blockers, as well as with antihypertensive drugs, hypnotics, tranquilizers, tricyclic antidepressants, phenothiazines, barbiturates, opioid analgesics, vasodilators, diuretics may cause an increase in the blood pressure index.
Simultaneous reception with funds for inhalation anesthesia increases the likelihood of suppression of myocardial function and the development of hypotension. Admission with Amidarone may cause arterial hypotension, bradycardia, asystole, ventricular fibrillation. Intravenous administration of Betapace and the use of Cartia (Diltiazem) increase the risk of a significant decrease in conduction and contractility of the myocardium. In this case, one can observe a depressive additive effect on AV and sinus nodes.
Simultaneous reception with oral hypoglycemic agents, insulin or with increased physical exertion, there is a risk of lowering the level of glucose. Admission with clonidine causes paradoxical arterial hypertension. If the patient receives beta-adrenergic receptors, then in the case of a sharp cancellation, it is possible to develop a severe degree of hypertension. Perhaps this is due to an increase in the content of catecholamines in the blood and a simultaneous increase in vasoconstrictor effects. Nifedipine is able to enhance the hypotensive effect.
What should I watch for while taking Betapace?
With extreme caution, the drug is recommended for use with liver and kidney pathologies. It is administered with caution in the recently transferred myocardial infarction, at any stage of diabetes mellitus, in renal diseases, psoriasis, thyrotoxicosis, with depressions, the first degree of atrioventricular node blockade, a drop in the concentration of calcium and magnesium, changes in the water-salt balance. Betapace should be taken with caution by patients over the age of 60 years.
What side effects may I notice from Generic Betapace?
Most often after taking drug observed bradycardia, blockade of the atrioventricular node, spasm of the bronchi, a drop in blood pressure, as well as an increased manifestation of signs of heart failure. On the background of therapy, there may be increased fatigue, dizziness, headache, drowsiness, mood lability, muscle weakness. Some patients showed a decrease in limb temperature, flatulence, stools, abdominal pain, sleep disorders, dry mouth, decreased potency and depression. In rare cases, the drug was accompanied by skin reactions of an allergic type, sensory disorders, hypoglycemia, conjunctivitis and inflammation of the cornea of the eye. Sometimes single cases of development of fever, attacks of stenocardia, syncopal conditions were recorded.
Where can I keep Betapace?
Shelf life of the drug is 5 years. It is stored at a temperature of 15 to 25 °, away from children. Also you can buy Betapace without prescription in Denmark online pharmacy.
