The pharmacological action is inhibition of dihydrofolate reductase. It is used as an anticancer and cytostatic agent. The composition of the drug is able to inhibit the synthesis of DNA repair and cell mitosis. Especially sensitive to the effects of the drug are malignant tumor tissues, epithelial cells of the mucous membrane of the digestive tract.
In what kind of disease treatmentRheumatrex is helpful?
Indications in which Generic Rheumatrex dosage have only positive reviews are presented in the following list:
Cancer of breast, lung, epidermis cancers of the head, cervical, ovarian, bladder, esophagus, colorectal, stomach, pancreas, testis;
What should I tell my health care provider before I takeGeneric Rheumatrex?
As contraindications to the use of the following may be a disorder or features of an organism:
Hypersensitivity to the active substance of the preparation;
Lactation or pregnancy;
Severe suppression of bone marrow hematopoiesis;
Hepatic or renal failure;
Ascites;
Gastrointestinal diseases;
dDehydration;
Diseases of viral or fungal origin.
How should I take Rheumatrex?
It is taken internally. The period of treatment and the dose is appointed by the doctor depending on the clinical indications based on scheme of chemotherapy.
Dosage information
Non-Hodgkin's Lymphoma - 15 mg per m2 of the patient's body once a day twice a week or 7.5 mg per m2 of body once a day for 5 days.
Trophoblastic tumors - from 15 mg to 30 mg once a day while continuing to 5 days. The therapy course is repeated 3-5 times making a break for 1 week (or more). Also, as an alternative can be administered 1 time in five days 50 mg making a break for 1 month. The course presupposes use of the drug in an amount of 300-350 mg;
Acute lymphoblastic leukemia - per m2 - 3.3 mg together with prednisolone. The dosage regimen after remission can be such as - 2 times 7 days per m2 or 15 mg per 1 kg of the patient weight of 2.5 mg every 2 weeks;
Mycosis fungoides - first appointed to take 2 times a day to 25 mg depending on the patient's response and hematological parameters the dose reduced or is canceled;
Psoriasis - per week 15-25 mg the dose should be gradually increased after is obtained optimal clinical effect the dose should be reduced to the level of the lowest effective;
Rheumatoid arthritis - once every 7 days for 7.5 mg by a single use or to split into 3 doses. To obtain the optimal clinical effect may be increased dose per week to about 20 mg. Once the desired result is obtained should be initiated gradual reducing to the lowest dose effective. Duration of therapy doctor chooses individually. Children with chronic juvenile arthritis are assigned dose based on each m2 - 15-30 mg, 1 time in 7 days.
What may interact with Generic Rheumatrex?
Since the drug is considered to be cytotoxic, the parallel use of any of drugs should be coordinated with the attending doctor. Considering features and properties of the drug, the patient's condition and drug interactions the doctor will make recommendations that will avoid the development of severe adverse reactions.
What should I watch for while taking Rheumatrex?
The cytotoxicity of Generic Rheumatrex requires careful treatment with it. Its appointment may only be carried out by specialist with extensive experience. Considering features of the action and properties of the drug, the doctor should inform the patient about the drug's ability to cause severe and sometimes fatal side effects, as well as the need to comply with strict regime to minimize them. Patients should avoid action of ultraviolet radiation or direct sunlight to avoid photosensitivity reactions. It is necessary to take into account the impact of the immune system during immunological tests and potential deterioration of response to vaccination. For this reason, after the drug for 3-12 months, the patient is not recommended immunizations.
During therapy for patients whose age is childbearing it is necessary to use reliable contraceptive methods, as well as after completion of treatment - for men over 3 months, and women - for 1 ovulatory cycle. Due to the fact that the drug has an effect on the central nervous system (drowsiness, dizziness) patients should avoid driving or controlling machinery during treatment.
What side effects may I notice from Generic Rheumatrex?
The following side effects may develop:
leukopenia;
anemia;
hypogammaglobulinemia;
nausea;
vomiting;
gingivitis;
loss of appetite;
erosive and ulcerative lesions and bleeding in the digestive tract;
headache;
blurred vision;
hemiparesis;
convulsions;
emotional lability;
aphasia.
Read all these effects especially if you buy Generic Rheumatrex online. When observed symptoms of overdose is necessary in the first 60 minutes to take specific antidote which is a calcium falinat. The dose should be equal or greater than the dosage of Methotrexate. The next input of antidote is performed depends on the concentration of drug in the blood. To prevent precipitation of the active substances or their metabolites is done in the renal system hydration of the body, and reducing of the level of alkali in urine.
Where can I keep Rheumatrex?
The drug should be stored in a dark place, far away from children at temperature 25 ° C.
