Drug medication Prometrium refers to the hormonal means of preventing pregnancy disruption.
The effect of the drug is based on the use of the toxic effect of main substance, which manifests itself by inhibiting the activity of oxytocin and the production of proglandin F2a. As a result, the contractile function of the uterus decreases. It is worth noting that the hormone is not toxic. It activates the transformation of the mucous membrane of the uterus into the secretory, and also reduces the excitability of the fallopian tubes and blocks the release of follicle-stimulating hormone, stops the production of gonadotropic hormones.
In addition, the drug is not able to change lipid and carbohydrate metabolism, blood composition, blood pressure. The only changes that occur with oral intake are sedation, which during pregnancy is more likely to have a positive effect.
In what kind of disease treatment Prometrium is helpful?
Reviews about Prometrium as well as laboratory studies have shown that this drug has proved to be an excellent preventive and therapeutic tool for:
• a cycle with delays and malfunctions;
• as a preventive remedy for myoma;
• in endocrine disorders that cause infertility;
• in endometriosis;
• at occurrence of a good-quality pathology (fibrous mastopathy);
• early menopause.
The duration of the course of therapy is affected by the nature of the pathology and the patient's age.
What should I tell my health care provider before I take Generic Prometrium?
The following conditions are contraindicated:
• renal and hepatic insufficiency;
• women during lactation;
• pregnant women in the 2nd and 3rd trimester (prescribed exclusively under the supervision of a doctor in emergency and in a hospital);
• in the presence of neoplasms of unknown origin;
• ailments of the cardiovascular system;
• hematosis;
• hormone-dependent neoplasms;
• ailments of the hematopoiesis;
• thrombosis;
• thrombophlebitis;
• liver failure;
• nephrolithiasis;
• post-infarction state.
How should I take Prometrium?
Since the vaginal walls are capable of absorbing tablets with the same efficacy as the mucosa in the mouth it can be taken either orally and vaginally.
Dosage information
It is necessary to take 200-300 mg of medicine per day. Time of reception: in the morning and in the evening before sleep (the most part of a dosage is taken in the evening).
If the luteal phase is insufficient, mastopathy, pronounced PMS medicament is taken from the 17th to the 26th day of the menstrual cycle.
With symptoms of pregnancy disruption. At 400 mg 8 hours before the disappearance of signs of breakdown. Further, the dosage is reduced to 200 mg- and the drug is prescribed 3 times a day.
Intra-vaginal administration. 1 capsule of 200 mg or 2 capsules of 100 mg each.
Violation of menstruation. Prometrium 200 mg daily for 10 days.
In the absence of progesterone production, the drug is prescribed from the 15th to the 25th day of the cycle in an amount of 100 mg, and from 26 days the dose rises to 600 mg per day if the fact of pregnancy is established. The course of admission in this mode is up to the 60th day.
Period of IVF. It is prescribed in the amount of 600 mg (200 mg every 8 hours).
What may interact with Generic Prometrium?
The intake of antibiotics, as well as barbiturates can change the amount of hormone in the blood plasma (increase or decrease the concentration of the hormone). In addition, due to taking drug Prometrium, the level of sugar decreases, because of this, there may be a need to increase the daily dosage of insulin.
Medication also affects hypotensive and diuretic medicines, enhancing their effect. You should carefully read the instruction especially if you buy Generic Prometrium online.
What should I watch for while taking Prometrium?
Prometrium cancellation is carried out gradually, with a smooth dose reduction (by 100 mg per week) because it is a hormonal drug and the body gets used to it. A sharp discontinuation of the drug may lead to hormonal failure and termination of pregnancy.
Thus it is necessary to be ready to that after a cancellation of a preparation within 2-7 days there can be blood spotting that is a normal reaction of an organism. If the number of excretions does not increase, then everything is fine, and you do not need to see a doctor. If the amount of secretions increases with time, you should consult your doctor.
What side effects may I notice from Prometrium?
The most pronounced unwanted reactions in the treatment of the hormonal Prometrium are random periodic bleeding, migraine attacks, dizziness, loss of vision, and increased bilirubin in the blood, increased or decreased appetite. To neutralize these Prometrium side effects, you need to increase the dose of estrogen.
With an increase in the severity of adverse reactions, it is necessary to immediately stop taking the drug.
Where can I keep Prometrium?
Shelf life of this drug is 3 years. If the packaging was damaged, then you need to check the blister with the pills for integrity. Do not use after expiration date. Also, the quality of the drug may decrease if you store it in a room with high humidity or in a sunlight place and at high temperature. This is a dangerous preparation for children so keep it out of their reach. Also you can buy Prometrium without prescription in Finland online pharmacy.
