Neggram (Nalidixic Acid)

What is Neggram?

Neggram’s active substance is nalidixic acid — a derivative of carboxylic acid. It is a chemotherapeutic agent that belongs to a group of gyrase inhibitors.

In what kind of disease treatment, Neggram is helpful?

Preparation is used to cure acute and recidivating urinary tract infections provoked by gram-negative bacteria: urethritis, cystitis, pyelonephritis, shigellosis and salmonellosis; to prevent infection at surgical procedures on the bladder, kidneys, ureters.

What should I tell my health care provider before I take Neggram?

A qualified specialist will never assign one or another remedy without adequate survey of the sick and without a thorough review of his medical records. Since healing one disease, medications might simultaneously exacerbate other violations, which is very dangerous. Therefore prohibitions for using Neggram are:

• Individual intolerance of the ingredients
• Kids up to 2 years
• Pregnancy
• Cerebral atherosclerosis
• Epilepsy
• Lack of glucose-6-phosphate dehydrogenase
• Renal and hepatic failure

How should I take Neggram?

Strictly adhere to the guidelines for the correct reception of a particular medicament, you do not have to take Neggram together with foodstuffs, but if your stomach hurts because of the medicine it is better to swallow it along with a meal. Never attempt to adjust the dosage of the antibiotic. The use of medicines in very small quantities is dangerous, because of higher probability of occurrence of resistant bacteria. Increased intakes are hazardous by manifestations negative reactions and an overdose. It is suggested to wash down any tablets only with pure, non-carbonated water. Do not to wash down antibiotics with milk and dairy products, as well as tea, coffee and juices (but there are exceptions, on which your health care provider will point out). Always keep equal time intervals between intakes of the antibiotic. It is necessary to maintain a constant concentration of Neggram in the blood. It must be convenient to get this medicine from many pharmaceutical distributors (you can choose one on the suggestion of your physician) or you might buy cheap Neggram online at the cheapest price.

Neggram dosage information

In acute ailments of the urinary tract Neggram dosage for full grown people is 1 g for 7 days (total diurnal amount — 4 g).

After clinical improvement it is possible to reduce dosage to 500 mg four times a day.

With prolonged cure or long-term prophylactic use one-time amount makes up to 500 mg (total diurnal amount — 2 g).

For kids over 10 years (weighing more than 30 kg) prescribe 2 g per day in 4 receptions.

What may interact with?

Neggram enhances the action of oral anticoagulants due to their replacement in areas of plasma protein binding.

Probenecid decreases the allocation nalidixic acid and enhances its concentration in plasma.

Nitrofuran or antacids inhibit the action of the nalidixic acid.

Neggram is not compatible with indirect anticoagulants, ethanol and medicines depressing the central nervous system.

What should I watch for while taking Neggram?

If you are prescribed a course of antibiotics, by no means stop healing as soon as you feel yourself better. You must continue reception for 2-3 days more after the improvement. If within 72 hours no improvement is observed, hence the exciter is resistant to this antibiotic and Neggram must be replaced.

During healing is advised to avoid prolonged staying under direct sunrays.

In sick with porphyria in anamnesis nalidixic acid can cause a relapse of the ailment.

If you have a need to give a urine sample, you must inform laboratory staff about medicines you are taking; Neggram can distort test results.

If the course lasts longer than 2 weeks, you need to check the function of the kidneys and liver.

Neggram does not affect the patient's ability to control of the vehicle or other mechanical means, but in the case of adverse events such as dizziness, hallucinations or sleepiness drivers of vehicles and individuals who work with precise mechanisms should be cautious.

Sometimes, aiming to make the healing more comfortable and with greater benefit, the physician may suggest to adhere to a special diet. Guidelines may vary for different patients, yet general tips are: give up fat foods, fried, smoked and canned foods; eliminate alcohol and sour fruits. Reception of antibiotics inhibit the liver, consequently, foodstuffs should prevent too much charge on liver. The diet includes more veggies, sweet fruit and white bread.

Neggram side effects

Absolutely harmless drugs do not exist. Apart from curative action, medications, as a rule, have side effects. Manifestations of the undesirable effects are often not sufficiently pronounced. Therefore, in all cases where you suspect that one or another malaise can be linked with taking Neggram, it is advised to consult a physician. Among these consequences are:

• Nausea, vomiting
• Diarrhea and stomach ache
• Rarely — headaches, vertigo
• Hallucinations, sleepiness
• Blurred vision
• Convulsions
• Rash with pruritus
• Muscle and joint pain
• Paresthesia
• Muscle weakness
• Leukopenia

Since nalidixic acid belongs to the group of quinolones may appear adverse effects such as, nephritic insufficiency and increased hepatic enzymes.

Where can I keep Neggram?

Neggram should be stored in containers made of light-shielding materials. Do not keep the medicine in the washroom, as the high humidity of the environment decreases the shelf life. The storage location should not be available for little kids and pets. Storing temperature has to be below 25°С. Shelf life — 3 years since the release. To guard yourself from any danger, consult with your personal physician on establishments where you can get Neggram. Or buy Neggram online without prescription.