Lamictal Dispersible (Lamotrigine)

What is Generic Lamictal Dispersible?

Lamictal Dispersible blocks voltage-gated sodium channels and break the process of forming seizures.

Active ingredient absorbed from the intestine completely. Maximum concentration observed after about 2.5 hours after taking.

Metabolic conversion held with the participation of the enzyme - glucuronyl transferase.

There are data that confirm the absence of significant differences in creatinine clearance in elderly and younger people.

During the 4-hour hemodialysis excreted approximately 20% of active ingredient. In renal pathologies the initial dose is calculated according to the standard pattern application of antiepileptics. In pathology kidney function of a serious nature usually lower the maintance dosage.

In what kind of disease treatment Lamictal Dispersible is helpful?

• Epilepsy ( including expression of such seizures as tonic-clonic and the ones developed because of Lennox-Gastaut syndrome) as part of comprehensive treatment (hereinafter referred to possible cancellation of other antiepileptics and continued therapy with just Lamictal Dispersible but only after full control of epilepsy on the background of the complex treatment) will be achieved.
• Absence seizures.
• In order to prevent mood disorders.

What should I tell my health care provider before I take Generic Lamictal Dispersible?

The only absolute contraindication to receiving Lamictal Dispersible is a hypersensitivit.

With caution physicians prescribe a drug in kidney failure.

How should I take Lamictal Dispersible?

Soluble tablets before use is necessary to fill with water until it cover the surface of the tablet.

A soluble tablet comprises 25, 50 or 100 mg of active ingredient.

Dosage information

In epilepsy: initiation of therapy is carried out in a single daily dose of 25 mg which is taken 14 days. Over the next 14 days a single daily dose increased to 50 mg, subsequently every 7-14 days it should be increased to 50-100 mg (for best therapeutic efficacy) which is supported by a dose of 100-200 mg taken once or twice in 24 hours.

Some patients for optimal efficiency of treatment require the appointment of higher doses up to 500 mg.

Bipolar affective disorder: for those people who are already taking Valproate initiation of therapy was shown in a dose of 25 mg taken every other day (the first 14 days). Then in the next 14 days they transferred to same dose every day. At the fifth week it can be increased to 50 mg in 1 or 2 divided doses. As a rule a maintaining dose of 100 mg is divided into 1 or 2 doses. The maximum permitted daily dose is 200 mg.

What may interact with Lamictal Dispersible?

Simultaneous treatment with valproic acid decreases its rate of metabolism and increases its half-life in almost 2 times.

Certain AEDs which are inducers of microsomal liver enzymes affect the acceleration of metabolism and glucuronidation of active ingredient.

Concurrent consumption with Carbamazepine or Risperidone can cause dizziness and other symptoms and they can disappear with decreasing of the doses.

Topiramate can increase its plasma concentration by 15%.

Minimal impacts on the allocation of 2-N-glucuronide have: Amitriptyline, Bupropion, Fluoxetine and Haloperidol.

What should I watch for while taking Lamictal Dispersible?

It has been proven that the poor efficiency of Lamotrigine including during an epileptic status may develop multiple organ dysfunction which may cause the patient's death.

Often it was reported about the development of rashes on the skin, usually noted during the first 2 months after initiation of therapy. Advantageously these lesions were mild and resolved without any treatment but occasionally severe cases were observed which required discontinuation of taking and hospitalization of the patient.

Mild rash usually doze independent and is a symptom of hypersensitivity whereas Lyell syndrome and Stevens-Johnson in 100% dependent on the dose.

It should be remembered that if you take AEDs then you can be at risk of suicide and therefore need to constantly check their psychological state.

Lamictal Dispersible assignment during pregnancy is possible only when the benefit of therapy is higher than the risk to the fetus.

What side effects may I notice from Generic Lamictal Dispersible?

CNS:

• anxiety;
• dizziness;
• irritability;
• headache;
• drowsiness;
• tiredness;
• insomnia;
• imbalance;
• nystagmus;
• tremors;
• ataxia;
• tics;
• aggressiveness;
• hallucinations;
• agitation;
• confusion;
• movement disorders;
• choreoathetosis;
• extrapyramidal disorders;
• increased frequency of seizures.

Skin and subcutaneous tissue:

• rash on the skin;
• exudative erythema multiforme.

Usually a rash on the skin is observed during the first 2 months and disappears when you cancel the treatment.

Blood and lymphatic system:

• leukopenia;
• agranulocytosis;
• neutropenia;
• anemia;
• aplastic anemia.

The immune system:

• hypersensitivity (mainly manifested by fever, facial edema, hematologic disorders, DIC syndrome, liver disease).

Organs of vision:

• conjunctivitis;
• diplopia.

Digestive system:

• nausea with possible vomiting;
• diarrhea;
• elevation of liver enzymes;
• reduction of liver function;
• liver failure.

Musculoskeletal System:

• back pain;
• arthralgia.

Rapid drug discontinuance may lead to more frequent observed seizures (withdrawal syndrome).

Where can I keep Lamictal Dispersible?

Keep the drug in a dry dark place out of reach of children at the temperature 25 degrees.