Furadantin (Nitrofurantoin)

What is Furadantin?

Furadantin (nitrofurantoin) is a synthetic antimicrobial agent, nitrofuran derivative. Has a bacteriostatic effect, but it can act bactericidal, depending on the concentration and the susceptibility of bacteria.

In what kind of disease treatment, Furadantin is helpful?

The bases for the application of Furadantin are bacterial (acute and chronic complicated and without complications) illnesses of the genitourinary system (cystitis, urethritis, pyelonephritis); prophylaxis of bacterial complications during operations on organs of the urogenital tract or diagnostic examinations.

What should I tell my health care provider before I take Furadantin?

• Intolerance to the formulation components (even in the past)
• Failure of renal function of severe degree
• Hepatic failure against a background of chronic hepatitis and hepatic cirrhosis
• Severe cardiac insufficiency
• Disruption of glucose-6-phosphate dehydrogenase enzyme
• Must be avoided by future and nursing mothers
• Infants under 1 month

How should I take Furadantin?

Beginning the therapy is important to bear in mind the major peculiarities of the application of antibacterial agents. Take Furadantin on an empty stomach during meals (therefore increases bioavailability). Scrupulously comply with time and frequency of administration. The general rule: stick with equal intervals between receptions of tablets. Thus there is a constant concentration of medicament in the blood. For many people information about the multiplicity of reception is incomprehensible, let’s imagine a situation in which you need to take the pills 3 times daily. This implies that intake must be carried out every 8 hours, not more and not less. If 2 times daily then use the tablets every 12 hours. If once daily: if you took a pill for the first time at 5 pm, then the next day at 5 pm you have to take the next one. Be sure to drink the tablets with water (at least half a glass), water should be cool and clean. Only in this case it would help you to swallow the pill and will have no effect on its ingredients. Ask your physician where you can buy the Furadantin, the professional is able to advice you the most reliable USA drugstore, or purchase Furadantin online.

Furadantin dosage information

For full grown people: 50-100 mg 4 times a day.

In order to determine the correct portion of Furadantin for kids use the following formula: 5.7 mg / kg of body weight per day, taken in four receptions.

If the therapy extends for a lengthy period, there is a need to change the rules of reception. For mature people: 50-100 mg 1 time in the evening; for kids — 1 mg / kg in 1-2 admissions.

What may interact with?

Do not apply together with fluoroquinolones, quinolones, since such combination could lead to drastic reduction in the activity of Furadantin.

Carefully appoint with preparations increasing the excretion of uric acid from the organism as it reduces the excretion of Furadantin and enhanced the risk of its undesirable events.

What should I watch for while taking Furadantin?

In patients with anemia, electrolyte imbalance, kidney disease, deficiency of vitamins B enhances the probability of occurrence of peripheral neuropathy.

Administration of the antibiotic requires a significant reduction of physical activity and sometimes complete abandonment of the workout.

In order the therapy to be less stressful follow a special diet. It is worth to give up from greasy foods, roasted, smoked and preserved products, exclude acidic fruits.

In the first days of therapy pay particular attention to monitoring your own condition. If within three days you have not noticed any changes for the better, then it means that causative agent is resistant to Furadantin, it would be wise to select another medicine.

Never attempt to adjust the dosage of Furadantin in the treatment process. Small doses of antibiotics are dangerous and influence the formation of bacterial resistance. For example, if you think that 2 tablets 4 times a day is a bit too much, and 1 tablet 3 times a day seems much better, then it is likely that soon you’ll need stronger injections, as the tablets will cease to act. Using large doses is also not safe, since it leads to an overdose and adverse events.

During therapy, the first symptoms of the sickness are usually removed after a few days, and many mistakenly stop using pills believing these few days are enough, but in fact the greatest harm to the organism provide these short uncompleted courses. Because bacteria do not die completely, as after a full course, but become resistant to Furadantin. Thus, incomplete course contributes to the evolutionary stability of microorganisms to Furadantin.

At the stage of pregnancy planning is better to completely abandon the use of Furadantin, as well as all substances that have harmful effects on the fetus. This applies also to women who are already expecting a baby. Nursing mothers, who have to be treated with Furadantin need to consider the safety of this medicine for the baby. Please consult with a physician.

Furadantin side effects

• Vomiting, vertigo, nausea, headaches
• Arthralgia, myalgia, nystagmus, anaphylactic shock
• Lupus like syndrome, fever and skin eruption, eosinophilia
• Somnolence, cough, pain in the thorax, bronchial obstruction, interstitial changes in the pulmonary tissue
• Hepatitis, pancreatitis, cholestatic syndrome, pseudomembranous enterocolitis, diarrhea
• Peripheral neuropathy, stomach ache

Long-term application of Furadantin is hazardous because enhances the likelihood of developing malignant renal tumors.

Nitrofurantoin and its derivatives and metabolites have a toxic impact on lungs. In one person out of 5000 after undergoing a single course of the medication develop shortness of breath, cough, fever, eosinophilia, myalgia and bronchospasm. Prolonged treatment with the agent may result in lobar infiltration, pleural exudation, vasculitis, interstitial inflammation.

In 1 in 20 000 people intake of a given agent causes pulmonary fibrosis and other toxic irreversible ruination to tissue of the lungs. If therapy is performed again, the risk of this kind of harm is greatly increased.

Allergic reactions that occur during therapy disappear on their own after cessation of therapy.

Where can I keep Furadantin?

Make sure that kids and house animals will not be able to get into the storage place; it must be dry and darkened. Suitable storage temperature should be between 15 and 25°C. This and even more guidelines you can get from a pharmacist in a Canada drugstore or in any other medical institute, or attentively read the information leaflet, which you can get when purchasing Furadantin securely online.