Celebrex (Celecoxib)

What is Celebrex?

It is an anti-inflammatory and antirheumatic agent, NSAID.

In what kind of disease treatment, Celebrex is helpful?

Indicators for application are symptomatic osteoarthritis and rheumatoid arthritis, acute pain, primary dysmenorrhea, in addition to conventional therapy for colorectal adenomatous polyps.

What should I tell my health care provider before I take Celebrex?

Generic Celebrex is prohibited for people with notorious susceptibility to any ingredient of the medication; diseased with known heightened sensitivity to sulfonamides. It is not assigned at presence of known allergy to any medication of category of non-steroidal anti-inflammatory agents. It is contraindicated after coronary bypass operations. Do not give the remedy to kids, as there is no proof of the security of its application in young aged. Don`t take given preparation in the last trimester of pregnancy. The product enters breast milk and could be potentially dangerous for the baby.

How should I take Celebrex?

The medication is taken orally, regardless of food intake; do not chew the capsule, drink with water. You will receive an instruction for use when you purchase the medication (similarly, if you buy generic Celebrex online with no prescription).

Celebrex dosage information

The standard suggested dose is 200 mg once or twice at the reception. If necessary, medication could be appointed to 200 mg twice a day.

Symptomatic therapy in rheumatoid arthritis: the suggested daily intake is 200-400 mg in 2 steps.

Symptomatic therapy in osteoarthritis: the advised daily intake of 200 mg must be consumed 1 per day or 100 mg 2 times a day. If required, may be appointed up to 400 mg in 2 divided doses.

Acute Pain and healing of primary dysmenorrhoea: suggested amount is 400 mg to start, if required, add 200 mg during the first 24 hours. Further encouraged amount is 200 mg twice/day.

Adenomatous polyps: suggested quantity is 400 mg twice daily at mealtime.

Elderly people: dose correction is not required. Nevertheless, in older people weighing less than 50 kg, healing should start with the smallest suggested dose.

Abnormal hepatic function: in sick with mild hepatic impairment dose correction is not required. In diseased with moderate hepatic cell dysfunction healing with Celebrex should begin with the smallest efficient amount.

Impaired renal function: in sick with mild to moderate renal failure intake correction is not required.

What may interact with?

Simultaneous application of Celebrex with Warfarin leads to high threat of bleeding.

Preparations containing fluconazole and Ketoconazole lead to doubled concentration of Celebrex in blood.

It is not allowed the simultaneous appointment of Celebrex and other NSAIDs. It is not rationally drinking alcohol while using this medication.

In combination with preparations of lithium, there is an increase of lithium in the blood approximately by 17%, so this combination requires careful monitoring and analysis of the sick.

This list requires amendment. To gain full list of potential combinations, provide your physician with information about all medications, foodstuffs and vitamins that you currently use.

What should I watch for while taking Celebrex?

If you take this medicine with fatty foods, its time of stay in maximal concentration in blood increases by approximately 4 hours and its absorption grows by 20%.

Elderly patients tend to have lower average body weight than those of a younger age, which is why in them, under other circumstances being equal, could be observed higher concentrations of Celebrex. For the similar reason, elderly women typically have a higher concentration of the medication in the plasma than older men.

In the representatives of the Negroid races AUC of Celebrex is by approximately 40% higher than in the Europeans. Reasons and clinical value of this data weren’t unexplored, so the healing of such diseased is advised to begin with a smallest effective dose. Celebrex, given its antipyretic effect, can reduce the diagnostic value of such a symptom, like fever, and influence the diagnosis an infection.

In the application of NSAIDs (COX-2) in sick after coronary artery bypass surgery for the healing of pain syndrome in the first 10-14 days, may increase the incidence of the stroke and cerebral circulatory disorders.

As well as all NSAIDs, Celebrex can cause elevated blood pressure, which can also cause complications in the cardiovascular system.

Influence of Celebrex on the ability to operate vehicles and control mechanisms has not been studied. However, based on the pharmacodynamic properties and the overall safety profile, it is unlikely that the medicine has such an influence.

Celebrex side effects

Admission Celebrex may be accompanied by displays of adverse effects in the form of:

•        Allergic reactions, flu-like condition, injuries

•        Peripheral edema

•        Abdominal pain, diarrhea, dyspepsia, flatulence, dental violations

•        Headache, dizziness

•        Insomnia, anxiety, somnolence rhinitis, sinusitis, upper breathing tract infections

•        Itching, rush

In the event of long reception of too big doses may grow manifestations of unwanted reactions. The cure of Celebrex overdose is the accelerated clearance of the drug from the organism and symptomatic therapy. Dialysis in this case is not effective.

Where can I keep Celebrex?

Keep in the original package. Do not consume medication if the capsules were in either way damaged. A period of storage after its manufacture date is 3 years. Avoid direct sunlight on the capsules; it significantly reduces the duration of storage of the medication. The temperature of the storage environment must be lower than 30°С. You can easily purchase the drug in your favorite UK drugstore or buy Generic Celebrex online.