It is a medicament for stimulating blood supply. It expands peripheral vessels, while reducing the oxygen demand of the heart muscle. Also it has a corona-dilating effect, reduces the volume of incoming blood to the right atrium, reduces the pressure of a small circle of blood flow, and redistributes the coronary flow of blood. Patients with coronary heart disease facilitate physical exercise.
Isordil Sublingual is an antianginal drug from the group of organic nitrates. After intake, the need of the heart for oxygen decreases because of a decrease in the load. The impact of medication is directed at:
• expansion of coronary and peripheral vessels;
• improvement of blood circulation in the damaged ischemia of the heart;
• lowering blood pressure;
• reducing the load on the heart muscle in people with heart failure.
The action of the drug is based on the formation of nitric oxide in the musculature of the vessels, as a result of which guanilate cyclase is activated, the amount of guanidine monophosphoric acid increases and muscles relax. The drug causes an expansion of the veins.
After ingestion, the drug is absorbed in the stomach and intestine tract. The maximum concentration of it is noted one hour after use. It is metabolized in the form of two metabolites, the half-life of which is observed after 2.5 and 5 hours. Their withdrawal is carried out by the intestine and kidneys. The effect of sublingual administration appears within 5 minutes.
In what kind of disease treatment Isordil Sublingual is helpful?
The drug is prescribed:
• patients who are diagnosed with coronary heart disease, including cupping and prophylaxis of angina pectoris;
• in complex therapy to patients after infarction;
• in combination with other medicines to patients with chronic pulmonary hypertension and heart failure.
What should I tell my health care provider before I take Generic Isordil Sublingual?
Isordil Sublingual drug is contraindicated in the following cases:
• intolerance to the components of the drug;
• congenital lactose intolerance;
• malabsorption of glucose-galactose.
The drug is not assigned to the following patients with:
• hemorrhagic stroke;
• trauma to the brain;
• anemia;
• closed angle glaucoma.
It is not helpful in exacerbation of myocardial infarction with arterial hypotension and with toxic pulmonary edema. The drug is contraindicated at a rate below 100 mm Hg. Art. systolic blood pressure, collapse, shock, pericarditis, patients with cardiac tamponade.
Medication Isordil Sublingual is not prescribed for people suffering from hypertrophic cardiomyopathy. With caution it is appointed in the disorder of cerebral circulation with a tendency to hypotension orthostatic and to patients with mitral and aortic stenosis, the elderly.
How should I take Isordil Sublingual?
The drug is taken sublingually (under the tongue).
Dosage information
The duration of the course of treatment and dosage of Isordil Sublingual is determined for each patient individually. It is administered to adults in the following dosages:
• For the prevention of angina and after infarction, 10 mg is suitable 3-4 times daily before meals in 30 minutes. The dose can be increased to 30 mg. The daily dosage should not exceed 180 mg. In order not to take preventive doses, it is possible to take 10 mg of the drug before the patient expects an attack within 30 minutes.
• In case of chronic heart failure, 20 mg of Isordil Sublingual is administered 3-4 times per day (oral).
• With pulmonary hypertension of complex therapy, the drug is prescribed 20 mg before meals 5 times a day, adhering to equal intervals of time.
• To prevent an attack of angina pectoris prescribed 10 mg sublingually. To quickly improve the patient's condition keep pill in the mouth until it dissolves.
Long-term use especially in large quantities and with small intervals between doses, it is possible to develop addiction. When the dose of the drug is increased, the pressure and the frequency of the contractions of the heart should be monitored. It is important to read the instruction carefully before the treatment, especially if you buy Generic Isordil Sublingual online.
What may interact with Generic Isordil Sublingual?
• Do not take it with Viagra, since there is a risk of developing infarction and hypotension of the arterial.
• Drugs that have enveloping and astringent properties, as well as adsorbents reduce the absorption process of the main substance.
• Taking antihypertensive drugs, calcium channel blockers, neuroleptics, peripheral vasodilators, tricyclic antidepressants, fad-inhibitors and ethanol together with the drug, the hypotensive effect is enhanced.
• Sharing with anticholinergic medications in the elderly can trigger memory impairment.
• Taking sympathomimetics can reduce the antianginal effect.
• The drug increases plasma concentrations and enhances the therapeutic effect of dihydroergotamine.
• Isordil Sublingual medication can reduce the effectiveness of norepinephrine.
What should I watch for while taking Isordil Sublingual?
During the reception patients should refuse to work with dangerous mechanisms and do not drive the car.
During pregnancy, Isordil Sublingual pills can be appointed by a doctor, but you must first compare the benefit to the mother and the negative impact on the unborn child. During the period of breastfeeding it is recommended to interrupt lactation for the duration of treatment with the drug.
What side effects may I notice from Generic Isordil Sublingual?
Medication is usually tolerated by patients normally, only in rare cases, Isordil Sublingual side effects may occur.
Gastrointestinal tract:
• nausea and vomiting;
• dryness of the oral mucosa;
• tingling of the tongue (when taken sublingually and buccally).
Central and peripheral nervous system:
• increased fatigue;
• dizziness;
• deterioration of sleep and wakefulness;
• rarely - ischemia of the brain;
• "nitrate" headache, which occurs at the beginning of application and disappears with its further application.
The cardiovascular system:
• arterial hypotension;
• tachycardia;
• orthostatic hypertension;
• fever, rush of blood to the face;
• rarely - increased attacks of angina pectoris;
• very rarely - lowering blood pressure, it is possible collapse.
An allergic reaction to the drug is also possible. It manifests itself in the form of skin itching, rash, hives.
Where can I keep Isordil Sublingual?
The drug should be stored in a dry place away from direct sunlight. Storage temperature is 7-15 degrees Celsius. Shelf life is 2 years. You can also buy Isordil Sublingual without prescription in international online pharmacies.
