Zestoretic (Lisinopril-hctz)

The hypotensive combined remedy Zestoretic has an effective antihypertensive, as well as diuretic effect on the human body. It reduces the amount of angiotensin II leads to a direct inhibition of the synthesis of aldosterone. The medication helps to reduce the degradation of bradykinin and simultaneously accelerate the synthesis of the Pg element.

Zestoretic lowers OPSS, blood pressure, significantly reduces preload on the heart and the body as a whole, as well as the pressure that is formed in the pulmonary capillaries. This medication causes an increase in IOC and increased tolerance to increased stress in people with chronic heart failure. The active component acts in such a way that a significant expansion of the blood artery occurs in a greater degree than in the veins. A number of effects are caused by exposure to tissue RAAS.

If the drug is taken by the patient for a sufficiently long period of time, then it has a clinically significant decrease in the severity of myocardial hypertrophy, as well as the walls of the bloody arteries of the resistive type. Various ACE inhibitors can prolong life expectancy in patients with chronic heart failure. Its active components affect the slowing down of the progression of left ventricular dysfunction in people who have had myocardial infarction, but do not have clinical manifestations of heart failure. The drug usually begins to act after one hour, and the maximum effect is observed after about seven hours. Its duration is one day.

The active ingredient hydrochlorothiazide is a thiazide diuretic, which has a diuretic effect due to a violation of the reabsorption of ions of such chemical elements as Na +, Cl- and K +, Mg2 +, as well as fluid contained in the distal nephron. Thanks to it, the process of elimination of Ca2 + ions and uric acid is slowed down. This active substance has some antihypertensive properties; its hypotensive effect develops as a result of the expansion of arterioles.

It should be noted that it practically does not affect normal blood pressure indicators. Diuretic action occurs in a couple of hours, the maximum of which is reached after about four hours and in most cases lasts up to twelve hours. Antihypertensive action occurs after several days, but to achieve the most optimal therapeutic result it may take three or four weeks. The combination of hydrochlorothiazide with lisinopril has an additive antihypertensive effect on the body.

This medicine can be used for patients who require combined therapy aimed at the treatment of hypertension.

Medication Zestoretic should not be taken by patients who have the following contraindications:

1. Individual hypersensitivity to the components of the drug.

2. Development of anuria.

3. Formation of angioedema.

4. Passage of hemodialysis using special high-flow membranes.

5. Symptoms of hypercalcemia.

6. Signs of porphyria.

7. Hepatic coma.

8. Diagnosis of severe diabetes mellitus.

9. The period of bearing of the child and feeding with breast milk.

10. Patients under the age of eighteen.

The drug is taken only internally.

The initial dosage is 5-10 mg once a day. If necessary, the dose may be increased to 20 mg once a day.

People who suffer from chronic renal insufficiency, the medication is prescribed only after a careful calculation of the dosage of each of the components of the drug. It is usually recommended to take 5-10 mg of tablets in the first days of treatment if moderate renal failure is diagnosed.

Patients can take the drug only after the dose is titrated to the individual active components. However, the dose should not be more than 5-10 mg. Also it is important to read the instruction carefully especially if you buy Generic Zestoretic online.

It is inadmissible to use a single-time drug Zestoretic with potassium-sparing drugs, since there is a risk of hyperkalemia. If it is necessary to take medications at the same time, systematic laboratory tests are needed to monitor the potassium level of blood serum.

The same applies to patients who have a history of renal insufficiency. When combined with diuretics and hypertensive drugs, admission is manifested by its enhanced hypertensive effect. Simultaneous use with gold preparations observed arterial hypotension, facial hyperemia, nausea and vomiting. Simultaneous reception with non-steroidal anti-inflammatory drugs, a decrease in the antihypertensive effect of lisinopril is observed. 

Symptomatic hypotension sometimes occurs as a result of taking the initial dose of the drug.

Similar situations are more common in patients who lost fluids and electrolytes due to the course of treatment with the use of diuretic medications. Therefore, you should stop taking diuretics several days before the start of Zestoretic therapy.

Some people who take this medication have a variety of Zestoretic side effects, which can be:

• Headaches with sharp dizziness.

• Clearly reduced blood pressure.

• Occurrence of pain in the chest area.

• Signs of tachycardia.

• Development of orthostatic hypotension.

• Signs of a bradycardia.

• Symptoms of chronic heart failure.

• AV conduction deterioration.

• Myocardial infarction.

• Nausea accompanied by vomiting.

• Appearance of abdominal pain.

• Increased dryness of the oral mucosa.

• Severe diarrhea.

• Symptoms of dyspepsia.

• Anorexia.

• Sharp change in taste.

• Development of hepatitis.

• The onset of pancreatitis, the appearance of jaundice.

• Deterioration of concentration of attention.

• Sharp mood changes.

• Paresthesia of the lower and upper extremities.

• Constant fatigue, a feeling of drowsiness.

• There are convulsive twitching of the lips, as well as the muscles of the hands and feet.

It is recommended to store the medicine in a dark place at a low temperature of air. It must be protected from small children. Shelf life of this drug is two years. You can also buy Zestoretic without prescription which is less expensive in Italy online pharmacy.