To date, medicine uses a large number of different drugs that are intended for the treatment and prevention of cardiovascular diseases. Such violations require the most effective and correctly selected therapy. In some cases, the use of the drug Xarelto is recommended.
This drug contains an active substance that contributes to reliable prevention of cardiac and vascular disorders. However, before using it, you should always consult your doctor. In tablets Xarelto contain the active substance rivaroxaban, which is a direct highly selective inhibitor of factor X. It is characterized by increased bioavailability when taking the drug inside. In a person taking this drug, a dose-dependent inhibition of factor X can be traced. The active ingredient has a pronounced dose-dependent effect on PV.
In what kind of disease treatment Xarelto is helpful?
Xarelto can be prescribed for the treatment of the following diseases:
1.Prevention of an attack of stroke in people who suffer from atrial fibrillation of non-valvular origin.
2.Development of deep vein thrombosis.
3.Severe thromboembolism of the pulmonary artery.
4.Preventing recurrence of pulmonary embolism.
What should I tell my health care provider before I take Generic Xarelto?
Xarelto tablets are not allowed for patients who have one or more contraindications:
1. Individual intolerance to various substances that make up the drug.
2. Different clinically significant and sufficiently severe bleeding, including gastrointestinal, as well as intracranial hemorrhages.
3. Damage that may lead to an increased risk of severe bleeding (gastrointestinal ulcer, malignant tumor, traumatic injuries of both the brain and spinal cord, after surgery on the eyes, spinal cord or brain, varicose veins in the esophagus, severe intracranial hemorrhages, an aneurysm of blood vessels, arteriovenous malformation).
4. Various liver diseases accompanied by coagulopathy.
5. Development of renal failure.
6. Individual lactose intolerance.
7. Deficiency of lactase, which is inherited.
8. Development of glucose-galactose malabsorption.
9. Children up to the age of eighteen.
10. The period of bearing of the child, the period of feeding the baby with breast milk.
How should I take Xarelto?
Tablets should be taken only inside while eating. They can be swallowed whole or crushed and mixed with water just before the reception.
Dosage information
To prevent the development of systemic thromboembolism or an attack of a stroke, the recommended dosage of this drug is 20 mg once a day.
However, if the normal function of the kidneys is disrupted, the dose should be reduced to 15 mg. The duration of the course of treatment is determined by the attending physician individually for each patient.
In order to treat PE and DVT, it is necessary to take 15 mg of the drug once a day for three weeks, and then increase the daily dosage to 20 mg. You can read in the instruction about the exact amount of drug you need to take if you buy Generic Xarelto online.
What may interact with Generic Xarelto?
1. Complex use with sufficiently strong inhibitors of the isoenzyme CYP3A4, as well as P-gp is the cause of a sharp decrease in hepatic or renal clearance, which leads to a significant increase in the systemic effect of tablets.
2. Combination with azole antifungal medication ketoconazole (Nizoral) causes an increase in the average equilibrium AUC of rivaroxaban several times.
3. Combination with HIV protease inhibitors of ritonavir is often the reason for the increased pharmacodynamic action of this drug.
4. When combined with Clarithromycin, the change in the properties of the drugs is clinically insignificant.
5. Erythromycin, if necessary, can be taken in parallel with drug Xarelto.
6. Combination of tablets with Fluconazole is the cause of clinically insignificant changes in AUC and Cmax medicament.
7. Do not combine with Dronedarone.
8. Rifampicin in most cases lowers the pharmacological efficacy of Xarelto.
9. Simultaneous treatment with various inducers of CYP3A4 leads to a sharp decrease in the level of rivaroxaban, which accumulates in the blood plasma.
10. Enoxaparin sodium increases the effectiveness of this drug.
11. It is necessary to combine very carefully with all possible anticoagulants, inhibitors of platelet aggregation, as well as NSAIDs.
12. It can be combined with Naproxen.
What should I watch for while taking Xarelto?
It is important during treatment to adhere to all conditions and to monitor the manifestations of Xarelto side effects.
What side effects may I notice from Generic Xarelto?
When taking the drug, patients may have complaints about various side effects:
•Development of anemia.
•Signs of thrombocytopenia.
•Symptoms of tachycardia.
•A strong outflow of blood in the eyes or conjunctiva.
•Increased bleeding gums.
•Rectal bleeding.
•Gastrointestinal bleeding.
•Appearing unpleasant pain in the area of the gastrointestinal tract.
•Attacks of nausea, which can be accompanied by severe vomiting.
•Diarrhea.
•Constipation for a long period of time.
•Severe indigestion.
•Increased dryness of the oral mucosa.
•Severe fever.
•Asthenia.
•Feeling of general weakness.
•Sharp deterioration in overall well-being.
•General malaise of the body.
•Increased anxiety.
•Clearly expressed jaundice.
•Dysfunction of the liver.
•Sometimes there are various liver diseases.
•Dermatitis of allergic etiology.
•Various manifestations of allergic reactions.
•A sharp increase in liver transaminase activity.
•Significant increase in the level of bilirubin, which is contained in the blood.
•Significant increase in the activity of LDH, AP, amylase, as well as GGT and lipase.
•The appearance of prolonged pain in the upper and lower extremities.
•Development of hemarthrosis.
•Severe bleeding in different muscle groups.
•Diseases of connective tissue.
•Occurrence of various diseases of the musculoskeletal system.
•Frequent attacks of dizziness.
•Short-term fainting.
•The appearance of a headache.
•Intracranial hemorrhage.
•Intracerebral haemorrhage.
•Frequent nosebleeds.
•Possibly spitting blood.
•Symptoms of hematuria.
•Manifestation of signs of menorrhagia.
•Bleeding from the urogenital tract.
•Significant increase in the concentration of urea, as well as creatinine.
•Itching is severe enough.
•Generalized itching is possible.
•Symptoms of ecchymosis.
•The surface of the skin on different parts of the body is covered with a rash.
•Skin or subcutaneous effusions.
•Hives.
•A sharp drop in blood pressure.
•The appearance of hematomas.
•Formation of angioedema.
•The onset of edema of allergic etiology.
•Impaired functions of the lymphatic system.
•The manifestation of the syndrome of elevated subfascial pressure, associated with a hemorrhage in the muscle tissue.
Where can I keep Xarelto?
To store these tablets you need at a completely dry and well ventilated place, which will be reliably protected from penetration of direct sunlight. Recommended air temperature does not exceed 30 ° C. You can also buy Xarelto without prescription in Canada online pharmacy.
