It is an antiviral drug, a synthetic analogue of nucleosides, whose mechanism of action consists in competitive inhibition of adenosine monophosphate dehydrogenase, which leads to inhibition of the synthesis of viral RNA and DNA.
Rebetol is available in the form of tablets, 0.2 g. The active ingredient of this drug is Ribavirin. The drug has the ability to quickly penetrate into the cell, affected by the virus, and metabolism in it. Antiviral effects are exerted by the active metabolites of the drug.
Action of these tablets is not entirely clear to medical scientists, but it is known that this drug suppresses the process of dividing the viral RNA cell and thereby inhibits the formation of new cells of the virus. In this case, this drug does not have any negative effect on the RNA functionality of normal and healthy cells. The most sensitive to this drug viruses are: the herpes virus, parainfluenza, influenza A and B, mumps, cytomegalovirus, and reoviruses. In addition, Rebetol is also active against the hepatitis C virus.
Bioavailability of this drug is forty five percent. Main substance is distributed in erythrocytes, in the secretion of the mucous membrane of the respiratory tract and in the blood serum. With prolonged use of the drug, its presence is determined in the cerebrospinal fluid. This drug is excreted from the body much more slowly than absorbed. The withdrawal period after the end of the course of treatment lasts up to three hundred hours. Excretion is carried out by the kidneys.
In what kind of disease treatment Rebetol is helpful?
A direct indication is the chronic form of viral hepatitis C. The drug is used in combination therapy, together with interferon preparations.
It is recommended that this medication is prescribed for patients who have not previously been treated, and for those who have already taken interferon alfa-2b or peginterferon alfa-2b. It is recommended that the drug be administered to those patients who have an individual non-susceptibility to monotherapy with interferon-containing drugs.
What should I tell my health care provider before I take Generic Rebetol?
This drug has a number of contraindications. It cannot be prescribed and used in the following cases of diseases:
• in increased sensitivity to any of the components that make up the drug;
• in severe heart failure;
• in myocardial infarction;
• in anemia of moderate to severe development (when the hemoglobin level is below eighty g / l);
• in severe renal failure;
• in hepatic insufficiency;
• in decompensated liver disease;
• for autoimmune diseases;
• in severe depression;
• in children up to the age of eighteen;
• during pregnancy and breastfeeding.
Caution when prescribing and using drug Rebetol should be observed in cases in which the patient has an anamnesis:
• thyroid gland diseases;
• violations of the process of blood coagulability;
• depression;
• in the elderly patient.
Since medication Rebetol has a teratogenic effect on the fetus, that is, it is capable of causing intrauterine malformations. During pregnancy it is highly not advisable to use this medication.
How should I take Rebetol?
The medication must be taken internally. Tablets should be swallowed whole, without violating their integrity, washed down with enough water, along with food.
Dosage information
The average daily dosage of the drug is 0.8-1.2 g. The daily dosage should be divided into two doses.
It is prescribed in combination therapy with interferon alpha 2b, which is administered subcutaneously three to three times per week or peginterferon alfa-2b at a dosage of 1.5 g per kilogram of patient weight once a week.
The duration of therapy is six to twelve months. The term of treating by the attending physician is determined depending on the indications. Be sure to read the instruction which you can find in the packaging if you buy Generic Rebetol online.
What may interact with Generic Rebetol?
Reduction of bioavailability of this drug occurs with its simultaneous use with drugs containing magnesium, aluminum and simethicone compounds.
Synergy of the effect is noted when it is combined with interferon alpha 2b or peginterferon alfa-2b.
In joint therapy with zidovudine or stavudine, this drug can cause HIV viremia. In this case, a change in the scheme of the entire therapy will be required.
What should I watch for while taking Rebetol?
In the absence of pregnancy during the therapy with and after Rebetol for seven months, women of childbearing age should use reliable methods of contraception.
Therapy with Rebetol should be performed exclusively under the strict supervision of a physician. Before starting the use of the drug, as well as in the second and fourth weeks of therapy, laboratory monitoring is needed, that is, a clinical blood test, urinalysis, determination of the level of creatinine, electrolytes and transaminases.
What side effects may I notice from Generic Rebetol?
Medication is able to cause a lot of side effects. Their manifestations will be as follows:
• from the cardiovascular system: decrease or increase in blood pressure, tachycardia, palpitations;
• from the side of the central nervous system: headache, dizziness, insomnia, weak body condition, depression, aggression, irritability, emotional lability, asthenia, confusion; extremely rare: tremor of extremities, hyperesthesia, fainting, increased level of muscle tone;
• on the part of the gastrointestinal tract: dryness in the oral cavity, nausea, diarrhea, tenderness in the abdomen, decreased appetite, constipation, flatulence;
• from the respiratory system: cough, pharyngitis, dyspnea, sinusitis;
• from the urinary system: prostatitis, dysmenorrhea, changes in libido, hot flashes;
• from the side of the immune system in the form of allergic reactions: urticaria, Quincke's edema, bronchospasm, anaphylactic shock, erythema, Stephen-Johnson syndrome.
In case of an overdose, the body's side reactions may increase. Treatment in this case should be symptomatic.
Where can I keep Rebetol?
Keep this drug at a temperature not exceeding twenty-five degrees Celsius. The storage location must be dark and out of the reach of children. The shelf life of the drug is two years from the date it was released from production, with intact packaging. It is a prescription drug but you can buy Rebetol without prescription in international pharmacies like Turkey online pharmacy.
