The drug is used for therapy of psoriasis, lymphoma, red lichen planus, vitiligo as a photosensitizing agent when applying photochemotherapy. In general, two psoralens are used - methoxalene and trioxysalene. The first is mainly used, as it is better absorbed.
To ensure effective treatment of psoriasis, the drug should be taken in combination with ultraviolet therapy under the supervision of a doctor. The agent can also be used in the treatment of skin diseases such as vitiligo, T-cell lymphoma of the skin and eczema.
Current reviews about Oxsoralen, allow you to get the necessary information about the level of quality, effectiveness of the selected medicine. Thus, an objective representation of the selected drug is formed.
When ingested, under the influence of long-wave UV irradiation, the interaction of DNA and methoxalene, decreases the proliferation of epidermal cells, the processes of melanogenesis are intensified. In the end, melanocytes move to the epidermal layer from the hair follicle. In psoriasis, inhibition of hyperproliferative processes occurs.
After receiving the maximum values, the main component reaches 1 to 3 hours. The time required for half-life is up to 2 hours. Rapid metabolism and accumulation of the drug occurs in the cells of the epidermis. With the proteins of blood, substances are bound, but this effect is reversible. It is completely excreted per day through the renal system.
In what kind of disease treatment Oxsoralen is helpful?
This medication has a beneficial effect in various neoplastic diseases, when applied in the form of monotherapy or as part of combination therapy with other cytotoxic drugs, hormones, radiation therapy or surgical treatment. In this regard, the dosing regimen can vary considerably depending on the clinical application.
The drug is used in dermatology before the PUVA therapy, since it has a pronounced photosensitizing effect. It is indicated for use in a number of skin diseases:
• vitiligo;
• mycosis mushroom-shaped;
• red flat deprive;
• psoriasis.
What should I tell my health care provider before I take Generic Oxsoralen?
Contraindications include:
• hepatic, renal failure;
• blood diseases;
• sensitivity to the constituents of the drug;
• malignant, benign tumors;
• diabetes;
• aphakia;
• age less than 12 years;
• increased photosensitivity;
• pregnancy, lactation;
• eye diseases.
• melanoma;
How should I take Oxsoralen?
This medication is taken internally. It should be taken with milk or low-fat food. Details about consumption you can read in the instruction if you buy Generic Oxsoralen online or ask your physician.
Dosage information
The dose is selected taking into account the body weight, about 0.6 milligrams per kilogram per 1 reception. It should be used two hours before the start of UV irradiation. For the PUVA procedure, an initial dosage of 0.25 to 0.5 J / cm2 is applied with a possible further increase.
What may interact with Generic Oxsoralen?
Poorly compatible Oxsoralen medication with any other photosensitizing components, among which:
• tetracyclines;
• halogen containing salicylates;
• Nalidixic acid;
• phenothiazines;
• sulfonamides.
What should I watch for while taking Oxsoralen?
Do not sunbath before taking the drug for one day, and after taking it is necessary to wear sunglasses for another 8 hours. You should try to avoid getting sunlight.
Additionally, you need to protect your eyes with sunglasses. They cannot be taken during the subsequent phototherapy. When conducting a PUVA therapy session, the patient should wear sunglasses.
Reception of Oxsoralen may not be justified for some groups of patients, therefore it is necessary to inform the doctor about the presence of pregnancy or its planning, breastfeeding, the presence of diseases, allergies, as well as about taking any prescription or over-the-counter medications, food supplements or herbal fees.
If you want to avoid Oxsoralen side effects and achieve maximum effectiveness in the treating course you should strictly adhere to the dosage and course of treatment prescribed by the treating specialist.
What side effects may I notice from Generic Oxsoralen?
• skin hyperemia;
• nausea;
• insomnia;
• symptoms of skin aging;
• decreased appetite.
• small head spinning;
• irritability;
• sleep disturbance;
• depressed state;
• nausea, less often vomiting;
• decreased appetite;
• redness of the skin;
• itching;
• burns with excessive UV;
• cataract, if you do not use eye protection;
• visible aging of the skin and its cancer.
In excessive exposure to UV rays burns and hyperemia occur.
If an allergic reaction occurs, seek medical help immediately. Typically, an allergic reaction manifests itself as difficulty in breathing and swallowing, chest tightness, swelling, skin rashes and hives.
Prolonged use of Oxsoralen threatens the development of skin cancer, cataract, and acceleration of the aging process of the skin.
In case of accidental overdose, it is recommended to use a specific antidote - calcium folinate. Introduction Calcium folinate should be started as soon as possible, preferably within the first hour, at a dose equal to or greater than the dose of Oxsoralen; subsequent doses are administered as needed, depending on the concentration of the main substance in the blood serum.
Where can I keep Oxsoralen?
The rules of keeping the drug are typical for medical substances – far away from children, at a dark place. Storage temperature is allowed from +15 to +24 degrees C. You can also buy Oxsoralen without prescription in international pharmacy Japan online pharmacy.
