Sovaldi is an antiviral drug of direct action of a new generation. It is an inhibitor of the NS5B RNA polymerase. It does not allow the virus to multiply and develop by copying its RNA. Unlike antiviral drugs of the old type, it acts only on the hepatitis C virus and refers to the so-called antiviral drugs of direct action (PEPA). The drug prevents the reproduction of the virus in the blood. Clinical studies have confirmed the high efficacy of the drug for all six genotypes.
Sofosbuvir which is the main component of medication is used with all genotypes of the virus also in combination therapy. The drug is in the form of tablets containing 400 mg. In addition to fewer side effects, the drug is more effective than previously synthesized antiviral drugs and also requires a 2-4 time short application period for effective elimination of the virus.
The main advantages of Sofosbuvir are high efficiency (97-100%), absence of side effects and complete preservation of the routine of life, does not affect the blood formula (like interferon-containing drugs), availability to receive and price, no likelihood of a virus return. Antiviral therapy on inhibitors (PPPA) is easily tolerated, does not require elaboration of complex reception schemes, does not require constant monitoring by a doctor - you just drink one tablet a day according to your chosen scheme and after 3 months there is no hepatitis (PCR negative). Medication is excreted from the body mainly (by 80%) with urine in the form of metabolites, partially excreted with feces and in a small amount is also output with exhaled air.
In what kind of disease treatmentSovaldi is helpful?
It is used to treat chronic viral hepatitis C as a major component of antiviral therapy in adult patients but usually professionals combine this medication with other to achieve better result. The drug can also be used if a patient simultaneously has HIV.
What should I tell my health care provider before I take Generic Sovaldi?
In general patients buy Sovaldi online and they should be warned that the drug should not be taken by children and adolescents under 18, during pregnancy or during lactation and of course with increased sensitivity to the active substance. Also, they cannot undergo Sofosbuvir therapy, as there have been no clinical trials for these groups. Women of reproductive age should take the drug with caution because this is a new drug and at the moment the effect of the drug on reproductive functions is not accurately established. Elderly patients and patients with renal and hepatic insufficiency should undergo treatment only under close supervision of a physician. For an easy degree of renal and hepatic insufficiency, dosage adjustment is not necessary.
How should I take Sovaldi?
It is taken once a day, one tablet. To take Sovaldi you should during eating, washing down with enough water. It is indicated for use in combination with other medications in adult patients but it is not used in monotherapy. Admission with fatty food slows the absorption of the drug, but increases the amount of its absorption. Patients usually swallow a pill without chewing or dividing into parts because of the bitter taste. If there is vomiting within 2 hours after taking the medication, you should take an extra pill. In case of vomiting after 2 hours, no additional pill is needed.
Dosage information
The scheme, success and duration of treatment depend both on the genotype of the virus and on the degree of lesion (fibrosis) of the liver. The standard treatment regimen (in the absence of severe liver damage - stage 4 fibrosis or cirrhosis) is 12 weeks.
What may interact with Generic Sovaldi?
During the course also it is necessary to combine the drug with other antiviral agents. Depending on the previous treatment the presence or absence of liver damages the genotype of the virus. Combined therapy may include Ribavirin, Daclatasvir, Ledipasvir, Velpatasvir (NS5A inhibitors) and other components. The peculiarities of the application of this scheme in different groups of patients can be clarified by the doctor.
What may interact with Generic Sovaldi?
Professionals forbid to take simultaneously with Telaprevir and Boceprivir. Before taking medication, read the instructions carefully. Also it is important to check if medications that you currently take or used to take during last two months.
What should I watch for while taking Sovaldi?
Do not take with intolerance of the active substance or any of the components. The medicine is not assigned to persons less than 18 years of age. Sovaldi is not given to pregnant women and women during lactation. Care should be taken when using in patients with tuberculosis and convulsive disorder. Before starting therapy, always consult your doctor. Professionals also warn that while taking this drug test results can vary, for example bilirubin in the blood.
What side effects may I notice from Generic Sovaldi?
Sovaldi side effects are not common thing and most patients did not experience them but still some did. The most common of these are fatigue, headache and nausea. The severity of side effects increases with combined therapy with interferon and other antiviral drugs. Often patients complain of fever (in most than 10% of cases). Very rarely patients complain to:
Insomnia;
Migraine;
Decreased appetite;
Convulsions; Dizziness;
Diarrhea, constipation;
Dry mouth;
Depression;
Irritability;
Anemia,
Neutropenia,
A decrease in the number of lymphocytes and platelets;
Skin rashes;
Itching; rash;
Pain in joints;
Myalgia;
Chills;
Cough;
Rhinopharyngitis;
Impaired vision;
Hair loss;
Dry skin;
Chest pain;
Asthenia.
Where can I keep Sovaldi?
Keep the drug in a dry place, protected from sun and inaccessible to children. Date of manufacture and shelf life are indicated on the packaging. Do not take the drug after the expiration date indicated on the package. Store the drug at a temperature of 15 to 30 ° C. Also you can buy Generic Sovaldi online in USA.
