The effect of the preparation is to create cross-linkages of RNA and DNA and inhibit protein synthesis. Numerous reviews about Cytoxan add up a good impression of its effectiveness.
The mechanism of action of the drug, the international name of which is Cyclophosphamide, is explained by the formation of crosslinks directly between the strands of RNA and DNA. Being in the body, it has the property of disintegrating in the cells of tumor formation.
In what kind of disease treatment Cytoxan is helpful?
It is an antitumor drug and is prescribed for the treatment of the following diseases:
• acute lymphoblastic, as well as chronic lymphocytic leukemia, multiple myeloma.
Used in combination with other antitumor drugs to treat:
• reticulosarcomas;
• germogenic tumors;
• Wilms tumor;
• Ewing's sarcoma;
• soft tissue sarcomas;
• cancer of the cervix, bladder, prostate;
• lung cancer.
Cytoxan drug is effective in progressing autoimmune diseases as an immunosuppressive agent, to suppress the reaction of the transplant rejection process.
In dermatology, it is used in vasculitis and in vesicular dermatoses that do not respond to other treatments. Usually this drug is used in hematology for the treatment of hemoblastosis and rheumatic diseases.
What should I tell my health care provider before I take Generic Cytoxan?
The drug has contraindications:
• hypersensitivity;
• bone marrow hypoplasia;
• pronounced cachexia;
• lakopenia and thrombocytopenia;
• severe functional disorders of the kidneys;
• retention of urination;
• cystitis;
• active infections;
• severe anemia;
• obvious violations of the functional work of the bone marrow;
• oncological diseases - terminal stages;
• pregnancy;
• lactation period.
Care must be taken in:
• gout in history;
• nefrorolithiasis;
• adrenalectomy;
• infiltration of bone marrow by tumor cells;
• severe diseases of the kidneys, liver, heart;
• anemia;
• cachexia.
How should I take Cytoxan?
Cytoxan pills should be taken internally, washing down with water. Do not crush or dissolve the tablet.
Dosage information
With each individual diagnosis, the doctor prescribes the most suitable dosage, but most doctors prescribe from 200 to 400 mg per day. This dose is selected based on the weight of the patient, that is, 3 and 4 mg per kg, respectively. After the course, supportive therapy should be prescribed and doctors reduce the dose to 0.05 - 1 g per day.
Cytoxan medication suppresses the proliferation of lymphocyte clones involved in the immune response. It affects mainly B - lymphocytes. It is prescribed at the rate of 1.0 - 1.5 mg, up to 3-4 mg / kg with satisfactory tolerability.
The usual prescription recommendation is to reduce the dosage of the order of up to 25% at a level of bilirubin in the blood serum in the aisles of 3.1-5 mg per 100 ml.
What may interact with Generic Cytoxan?
If the drug is used in conjunction with other antitumor drugs, you may need to reduce the dose of lymphocyte clones or other drugs. More detailed interactions you can find in a manufacturer’s instruction if you buy Generic Cytoxan online.
What should I watch for while taking Cytoxan?
It is very necessary to treat patients with existing heart diseases, as well as liver and kidneys expressed in severe form, impaired function of the bone marrow. You need to observe reliable types of contraception. When determining the likelihood of positive results and the likelihood of a potential risk when taking medication, it is important to consider the possibility of induction of a malignant tumor by the drug. It should be borne in mind that treatment may contribute to the occurrence of sterility in men and women, and in some cases it may be irreversible.
It is important to monitor the blood test, paying great attention to the number of platelets and neutrophils to understand the level of myelosuppression. To prevent hemorrhagic cystitis you should constantly monitor the analysis of urine and the number of red blood cells. If cystitis with signs of micro or macroscopic disease is detected, the drug should be stopped.
When an infection occurs, the dosage is reduced or the drug is stopped. For the entire period of use of the drug it is prohibited to use of alcoholic beverages. In case the drug was prescribed ten days after the operation with general anesthesia was performed, it is very important to inform the appointment of an anesthesiologist about this.
What side effects may I notice from Generic Cytoxan?
A slight decrease in white blood cells and platelets is possible on the 7-14th day of treatment. Approximately half of treatments leads to the development of hemorrhagic cystitis. To reduce the risk of this complication, patients are recommended to consume more fluid. Here you have a list of possible Cytoxan side effects:
cardiotoxicity;
lakopenia;
neutropenia;
impaired liver function;
alopecia;
cystitis;
feeling of nausea, anorexia;
hemorrhagic urethritis;
heart failure;
thrombocytopenia;
pain and discomfort in the abdominal area;
diarrhea or constipation;
stomatitis;
skin rash;
changing nails;
skin pigmentation;
fibrosis of the bladder;
necrosis of the renal tubules (possible fatal outcome).
Where can I keep Cytoxan?
Keep Cytoxan in a place protected from light and high humidity, out of reach of children, at a temperature of +10 ° C, not higher. Shelf life with observance of all requirements is 3 years. It is a prescription drug and the only way to buy Cytoxan without prescription is to choose international pharmacies like Sweden online pharmacy.
